1007375-07-6

Usage

Physical state

Colorless to pale yellow liquid

Odor

Faint aromatic

Usage

Building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds

Industry application

Pharmaceutical industry for the production of various medications

Role

Intermediate in the synthesis of organic compounds

Function

Precursor in the preparation of various organic compounds

Additional use

Reagent in organic synthesis

Safety

Handle with caution due to hazardous nature and chemical reactivity

Upstream product

• 88-18-6 2-tert-Butylphenol 
• 23159-87-7 2-bromo-6-(tert-butyl)phenol 
• 74-88-4 methyl iodide 

Downstream Products

• 1443670-14-1 2-tert-butyl-6-(octyltelluro)phenol 
• 1443670-18-5 2-tert-butyl-6-(octyltelluro)anisole 
• 1443670-20-9 2-tert-butyl-4-(octyltelluro)anisole 
• 1619266-33-9 C₁₅H₁₉NO 

Relevant academic research and scientific papers

Synthesis, characterization, and reactivity of a d2, Mo(IV) complex supported by a new OCO-trianionic pincer ligand

The new terphenyl pincer precursor 3,3″-di-tert-butyl-1,1′:3′,1″-terphenyl-2,2″-diol (1) is examined for its ability to support early transition metals as a trianionic ligand. Metalation proceeds smoothly at -35 °C with Mo(NMe2)4 to

Multi-faceted reactivity of alkyltellurophenols towards peroxyl radicals: Catalytic antioxidant versus thiol-depletion effect

Hydroxyaryl alkyl tellurides are effective antioxidants both in organic solution and aqueous biphasic systems. They react by an unconventional mechanism with ROO. radicals with rate constants as high as 107 M-1 s-1 at 303 K, outperforming common phenols. The reactions proceed by oxygen atom transfer to tellurium followed by hydrogen atom transfer to the resulting RO. radical from the phenolic OH. The reaction rates do not reflect the electronic properties of the ring substituents and, because the reactions occur in a solvent cage, quenching is more efficient when the OH and TeR groups have an ortho arrangement. In the presence of thiols, hydroxyaryl alkyl tellurides act as catalytic antioxidants towards both hydroperoxides (mimicking the glutathione peroxidases) and peroxyl radicals. The high efficiency of the quenching of the peroxyl radicals and hydroperoxides could be advantageous under normal cellular conditions, but pro-oxidative (thiol depletion) when thiol concentrations are low. Anti- and pro-oxidants: Hydroxyaryl alkyl tellurides are unconventional antioxidants able to quench chain-carrying peroxyl radicals with rate constants as high as 107 M-1 s-1 by a mechanism involving oxygen atom transfer to tellurium followed by reaction of the RO. radical with the phenol (see figure). They can also catalytically decompose both the ROO. radical and H2O2 in the presence of excess thiols. Copyright

Synthesis and stereochemical properties of "extended" biphenols bridged by ortho-, meta-, and para-phenylene spacers

A series of isomeric biphenols based on para- (1), meta- (2), and ortho- (3) terphenyl backbones was synthesized. Suzuki cross-coupling methodology was employed for the construction of the terphenyl backbone of their methyl-protected precursors (respectiv