1007382-48-0Relevant academic research and scientific papers
Synthesis of 7-substituted derivatives of 5, 8-dimethylisoquinoline
Nagao, Yukinori,Hirota, Katsuaki,Tokumaru, Mizuho,Kozawa, Kozo
, p. 593 - 602 (2007)
7-Bromo-5,8-dimethylisoquinoline was selectively synthesized by the bromination of 5,8-dimethylisoquinoline obtained in five steps from p-xylene as a starting material. Further,7-bromo-5,8-dimethylisoquinolinegave 7-amino-5,8-dimethylisoquinoline by the reaction with ammonia and various 7-anilino-5,8-dimethylisoquinolines via a palladium-catalyzed coupling reaction with anilines.
