1007392-84-8

Upstream product

• 149965-40-2 5-bromo-2-chlorobenzyl alcohol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 873782-26-4 ((5-bromo-2-chlorobenzyl)oxy)(tert-butyl)dimethylsilane 
• 946000-08-4 3-(((tert-butyldimethylsilyl)oxy)methyl)-4-chlorobenzaldehyde 
• 79667-91-7 2,2-difluoroethylamine hydrochloride 

Downstream Products

• 946001-72-5 [3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-benzyl]-(2,2-difluoro-ethyl)-carbamic acid tert-butyl ester 
• 946001-77-0 (4-chloro-3-formyl-benzyl)-(2,2-difluoro-ethyl)-carbamic acid tert-butyl ester 
• 946001-75-8 (4-chloro-3-hydroxymethyl-benzyl)-(2,2-difluoro-ethyl)-carbamic acid tert-butyl ester 
• 946001-80-5 (4-chloro-3-cyclopropylaminomethyl-benzyl)-(2,2-difluoro-ethyl)-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Secondary Amines as Renin Inhibitors

The invention relates to novel secondary amine derivatives of formula (I) and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.

Novel Piperidine Carboxylic Acid Amide Derivatives

The invention relates to novel piperidine carboxylic acid amide derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of these

SECONDARY AMINES AS RENIN INHIBITORS

The invention relates to novel secondary amine derivatives of formula (I) and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.