79667-91-7

Basic information

• Product Name: 2,2-DIFLUOROETHYLAMINE HYDROCHLORIDE
• Synonyms: 2,2-DIFLUOROETHYLAMINE HYDROCHLORIDE;2,2-Difluoro-1-ethanaMine Hydrochloride;1-Amino-2,2-difluoroethane hydrochloride;2,2-DifluoroethylaMine hydrochlorid
• CAS NO: 79667-91-7
• Molecular Formula: C₂H₅F₂N*ClH
• Molecular Weight: 117.53
• Product Categories: Aliphatics;Amines;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 79667-91-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 132-137°C (w/decomp)
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,2-DIFLUOROETHYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIFLUOROETHYLAMINE HYDROCHLORIDE(79667-91-7)
• EPA Substance Registry System: 2,2-DIFLUOROETHYLAMINE HYDROCHLORIDE(79667-91-7)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38-52-41-37/38-25
• Safety Statements: 26-36/37/39-45-39
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 79667-91-7(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 79667-91-7 differently. You can refer to the following data:
1. As a fluorinated aliphatic amine, 2,2-Difluoroethylamine hydrochloride can be used in preparation of wide range of pharmaceutical compounds including anti-tumor agents.
2. 2,2-Difluoroethylamine hydrochloride was recently reported to be used as a precursor for the "elusive" difluoromethyl diazomethane species (CF2HCHN2). The difluoromethyl diazomethane intermediate can be generated in situ in the presence of tert-butyl nitrite and a catalytic amount of acetic acid.

Upstream product

• 1389330-95-3 1-(2,2-difluoroethyl)pyrrolidine-2,5-dione 
• 778-69-8 N-(2,2-difluoro-ethyl)-phthalimide 
• 1310429-33-4 monoacetyl-2,2-difluoroethylamine 
• 93696-69-6 2,2-Difluornitroethan 
• 359-38-6 2,2-difluoroacetamide 

Downstream Products

• 359-13-7 difluoroethanol 
• 6832-13-9 diazoacetaldehyde 
• 1225380-87-9 tert-butyl 4-(2,2-difluoroethyl)piperazine-1-carboxylate 
• 1239235-02-9 2-({(2-(4-chlorophenyl)-1,3-thiazol-4-yl)methyl}sulfanyl)-6-((2,2-difluoroethyl)amino)-4-(4-(2-hydroxyethoxy)phenyl)pyridine-3,5-dicarbonitrile 
• 1007392-84-8 [3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-benzyl]-(2,2-difluoro-ethyl)-amine 
• 118714-31-1 1-(2,2-Difluoro-ethyl)-3-[4-(1H-imidazol-4-yl)-phenyl]-thiourea 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF 2,2-DIFLUOROETHYLAMINE

A process for the preparation of 2,2-difluoroethylamine, comprising the reaction of 2,2-difluoro-1-chloroethane with an imide of the formula (II) in the presence of an acid scavenger, to give a compound of the formula (III) in which, in the compounds of the formulae (II) and (III), R1 and R2 are, each independently of one another, hydrogen or C1-C6-alkyl or R1 and R2 form, together with the carbon atoms to which they are bonded, a six-membered aromatic ring which is optionally substituted; and the cleavage of 2,2-difluoroethylamine by reaction of the compound of the formula (III) with acid, base or hydrazine.

Process for Preparing 2,2-difluoroethylamine by Hydrogenating 1,1-difluoro-2-nitroethane

Process for preparing 2,2-difluoroethylamine, characterized in that 1,1-difluoro-2-nitroethane is subjected to a catalytic hydrogenation.