100747-54-4

Upstream product

• 611-20-1 salicylonitrile 
• 58792-15-7 5-Phenyl-1,2,3-thiadiazole-4-carboxylic acid 
• 52059-59-3 5-(o-hydroxyphenyl)-1,3,4-oxathiazol-2-one 
• 65-45-2 salicylamide 
• 100747-53-3 Phenyl-propynoic acid 2-(2-oxo-[1,3,4]oxathiazol-5-yl)-phenyl ester 
• 100747-68-0 (E)-3-Phenyl-acrylic acid 2-(2-oxo-[1,3,4]oxathiazol-5-yl)-phenyl ester 

Relevant academic research and scientific papers

Synthesis of Bicyclic Isothiazoles through an Intramolecular Rhodium-Catalyzed Transannulation of Cyanothiadiazoles

An intramolecular rhodium-catalyzed transannulation of readily available cyanothiadiazoles containing an ester, amide, or ether as a linker is described. It provides a wide range of bicyclic isothiazoles in good to excellent yields together with the release of molecular nitrogen. These results indicate that the carbon atom in the α-thiavinyl carbene is nucleophilic and that the sulfur atom is electrophilic.

Production method of isothiazole derivatives

The present invention refers to isothiazole derivatives of manufacturing method relates to, more specifically of the present invention isothiazole derivatives of chlorogenic manufacturing method (1, 5 - cyclo jade other d n) rhodium (I) dimer catalyst and 1, 1' - bis ([...]) ferroceneIntermolecular cyclization reaction in the presence of 3 - 3, 4 - substituted isothiazole derivatives or intra-reaction bonded isothiazole derivatives with high selectivity can be obtained and yield very efficient method are disclosed. (by machine translation)

INTRAMOLECULAR CYCLOADDITION REACTIONS INVOLVING NITRILE SULPHIDES

ortho-(Phenylpropioloxy)benzonitrile sulphide, generated in situ by thermal decarboxylation of the oxathiazolone (1), undergoes intramolecular 1,3-dipolar cycloaddition forming the chromenoisothiazole (4a); ortho-cinnamoylbenzonitrile sulphides also yield (4), together with nitrile, chromenoquinoline and amino-chromene by-products.