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CAS

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1007488-73-4

[1-(propan-2-yl)-1H-pyrazol-5-yl]methanol, a pyrazole derivative with the molecular formula C8H12N2O, is a white to off-white solid at room temperature. It is soluble in organic solvents such as ethanol and ether and is used as a building block in the production of various pharmaceutical and agrochemical compounds.

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  • 1007488-73-4 Structure

  • Basic information

    1. Product Name: [1-(propan-2-yl)-1H-pyrazol-5-yl]methanol
    2. Synonyms:
    3. CAS NO:1007488-73-4
    4. Molecular Formula:
    5. Molecular Weight: 140.185
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1007488-73-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: [1-(propan-2-yl)-1H-pyrazol-5-yl]methanol(CAS DataBase Reference)
    10. NIST Chemistry Reference: [1-(propan-2-yl)-1H-pyrazol-5-yl]methanol(1007488-73-4)
    11. EPA Substance Registry System: [1-(propan-2-yl)-1H-pyrazol-5-yl]methanol(1007488-73-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1007488-73-4(Hazardous Substances Data)

1007488-73-4 Usage

Uses

Used in Pharmaceutical Industry:
[1-(propan-2-yl)-1H-pyrazol-5-yl]methanol is used as a reagent for the synthesis of heterocyclic compounds, which are essential in the development of new pharmaceuticals. Its role in creating these compounds aids in the advancement of drug discovery and the treatment of various medical conditions.
Used in Agrochemical Industry:
In the agrochemical industry, [1-(propan-2-yl)-1H-pyrazol-5-yl]methanol is used as an intermediate for the production of various agrochemical compounds. Its application in this field contributes to the development of new products that can enhance crop protection and improve agricultural practices.
Used in Organic Synthesis:
[1-(propan-2-yl)-1H-pyrazol-5-yl]methanol is also utilized in organic synthesis as a building block for creating a wide range of chemical compounds. Its versatility in this area allows for the development of new materials and substances with potential applications in various industries.
It is crucial to handle [1-(propan-2-yl)-1H-pyrazol-5-yl]methanol with care and adhere to all safety guidelines and regulations when using it in a laboratory or industrial setting to ensure the safety of both the users and the environment.

Check Digit Verification of cas no

The CAS Registry Mumber 1007488-73-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,7,4,8 and 8 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1007488-73:
(9*1)+(8*0)+(7*0)+(6*7)+(5*4)+(4*8)+(3*8)+(2*7)+(1*3)=144
144 % 10 = 4
So 1007488-73-4 is a valid CAS Registry Number.

1007488-73-4Downstream Products

1007488-73-4Relevant articles and documents

Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor

Szlavik, Zoltan,Csekei, Marton,Paczal, Attila,Szabo, Zoltan B.,Sipos, Szabolcs,Radics, Gabor,Proszenyak, Agnes,Balint, Balazs,Murray, James,Davidson, James,Chen, Ijen,Dokurno, Pawel,Surgenor, Allan E,Daniels, Zoe Marie,Hubbard, Roderick E.,Le Toumelin-Braizat, Ga?tane,Claperon, Audrey,Lysiak-Auvity, Ga?lle,Girard, Anne-Marie,Bruno, Alain,Chanrion, Maia,Colland, Frédéric,Maragno, Ana-Leticia,Demarles, Didier,Geneste, Olivier,Kotschy, Andras

, p. 13762 - 13795 (2020/12/02)

Myeloid cell leukemia 1 (Mcl-1) has emerged as an attractive target for cancer therapy. It is an antiapoptotic member of the Bcl-2 family of proteins, whose upregulation in human cancers is associated with high tumor grade, poor survival, and resistance to chemotherapy. Here we report the discovery of our clinical candidate S64315, a selective small molecule inhibitor of Mcl-1. Starting from a fragment derived lead compound, we have conducted structure guided optimization that has led to a significant (3 log) improvement of target affinity as well as cellular potency. The presence of hindered rotation along a biaryl axis has conferred high selectivity to the compounds against other members of the Bcl-2 family. During optimization, we have also established predictive PD markers of Mcl-1 inhibition and achieved both efficient in vitro cell killing and tumor regression in Mcl-1 dependent cancer models. The preclinical candidate has drug-like properties that have enabled its development and entry into clinical trials.

NEW THIENOPYRIMIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

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Page/Page column 132; 133; 165, (2015/07/15)

Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R12, X, A and n are as defined in the description.

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