1007583-05-2Relevant articles and documents
Heteropoly acids as heterogeneous and reusable catalyst for α-thiocyanation of ketones
Chaskar, Atul C.,Yadav, Arun A.,Langi, Bhushan P.,Murugappan, Anita,Shah, Chetan
, p. 2850 - 2856 (2010)
Simple, efficient, and mild method for -thiocyanation of ketones in presence of heteropolyacid has been developed. This methodology offered -oxothiocyanates in good to excellent yields at room temperature in a highly selective manner. The catalyst could b
Trichloroisocyanuric acid as a novel and versatile reagent for the rapid α-thiocyanation of ketones
Liu, Shanshan,Guo, Zhihao,Wang, Yaqin,Wang, Tianbao,Wu, Liqiang
experimental part, p. 3760 - 3762 (2012/01/07)
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Negishi cross-couplings compatible with unprotected amide functions
Manolikakes, Georg,Dong, Zhibing,Mayr, Herbert,Li, Jinshan,Knochel, Paul
supporting information; experimental part, p. 1324 - 1328 (2009/09/04)
The reaction conditions that allow a general Pd-catalyzed Negishi cross-coupling of a functionalized alkyl, aryl, heteroaryl, and benzylic zinc reagents with aryl acidic hydrogens were investigated. A dry and argon flushed 10 mL Schlenk-tube was charged with N-benzyl-4-bromobenzamide, Pd(OAc) 2, S-PHOS, and THF. 3-pentanoyl-benzylzinc chloride was added slowly over 90 minutes with a syringe pump. The reaction mixture was stirred for 1 hour at 25 °C. The reaction mixture was quenched with a saturated NH 4Cl solution and extracted with diethyl ether. The combined phases were then washed with a aqueous thiourea solution and dried over Na 2SO4. It was observed that the mild conditions considerably increase the ability of the Negishi cross-coupling in the synthesis of complex molecules and natural products.