1007583-05-2

Upstream product

• 1147550-11-5 ammonium thiocyanate 
• 2142-63-4 1-(3-Bromophenyl)ethanone 
• 540-72-7 sodium thiocyanide 
• 18523-22-3 2,3'-dibromoacetophenone 

Downstream Products

• 1429397-43-2 2,2'-disulfanediylbis[1-(3-bromophenyl)ethanone] 
• 1007583-07-4 2-{[4-(3-bromophenyl)-1,3-thiazol-2-yl]amino}-2-methylpropan-1-ol 
• 886367-82-4 2-bromo-4-(3-bromo-phenyl)-thiazole 

Relevant academic research and scientific papers

Heteropoly acids as heterogeneous and reusable catalyst for α-thiocyanation of ketones

Simple, efficient, and mild method for -thiocyanation of ketones in presence of heteropolyacid has been developed. This methodology offered -oxothiocyanates in good to excellent yields at room temperature in a highly selective manner. The catalyst could b

Efficient α-thiocyanation of ketones using pyridinium hydrobromide perbromide

The direct α-thiocyanation of ketones with ammonium thiocyanate has been achieved using pyridinium hydrobromide perbromide under mild and neutral conditions to produce α-ketothiocyanates in excellent yields and with high selectivity. Copyright

I2O5 as a mild, inexpensive, and environmentally benign oxidant for the α-thiocyanation of ketones

-Thiocyanation of various ketones has been achieved using ammonium thiocyanate as a thiocyanation reagent and I2O5 as an oxidant in methanol solution at room temperature. Figure Presented.

Negishi cross-couplings compatible with unprotected amide functions

The reaction conditions that allow a general Pd-catalyzed Negishi cross-coupling of a functionalized alkyl, aryl, heteroaryl, and benzylic zinc reagents with aryl acidic hydrogens were investigated. A dry and argon flushed 10 mL Schlenk-tube was charged with N-benzyl-4-bromobenzamide, Pd(OAc) 2, S-PHOS, and THF. 3-pentanoyl-benzylzinc chloride was added slowly over 90 minutes with a syringe pump. The reaction mixture was stirred for 1 hour at 25 °C. The reaction mixture was quenched with a saturated NH 4Cl solution and extracted with diethyl ether. The combined phases were then washed with a aqueous thiourea solution and dried over Na 2SO4. It was observed that the mild conditions considerably increase the ability of the Negishi cross-coupling in the synthesis of complex molecules and natural products.