1007661-45-1Relevant academic research and scientific papers
Conformational analysis of N→BH3, N→BF3, and N-CH3 + complexes with ibuprofen-derivative amides
Romero-Chávez, Maria M.,Pineda-Urbina, Kayim,Maga?a-Vergara, Nancy E.,Vázquez-Cárdenas, Rubén,Gómez-Sandoval, Zeferino,Ramos-Organillo, ángel
, (2017)
The synthesis and structural characterization of novel amine-borane adducts of ibuprofen derivatives are presented. The changes of the electron density on the carbonyl and pyridine ring after formation of N→BH3, N→BF3, and N-CH3 + have been confirmed by 1H, 11B, 13C, and 19F NMR, further supported by homonuclear and heteronuclear correlations. Moreover, electrostatic interactions —H+···?F and the nonclassical H+···?H— were identified by NMR spectra. The analysis of the resulting molecular structures offered insights on the 2-aminopyridine N→B adducts. The N→BH3 adduct formed a single molecular arrangement, both in C6D6 and CDCl3. The same behavior was observed for the N→BF3 adduct in CDCl3. However, two conformers of this adduct were detected in C6D6. All adduct geometries were corroborated by density functional theory computational calculations.
2-ARYL-PROPIONAMIDE DERIVATIVES USEFUL AS BRADYKININ RECEPTOR ANTAGONISTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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Page/Page column 24, (2011/05/11)
(R,S) 2-aryl-propionamide derivatives, or their single enantiomers (R) and (S) are disclosed useful in the treatment or prevention of symptoms and disorders such as pain and inflammation associated with the bradykinin B 1 pathway.
2-aryl-propionamide derivatives useful as bradykinin receptor antagonists and pharmaceutical compositions containing them
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Page/Page column 14, (2011/05/08)
(R,S) 2-aryl-propionamide derivatives, or their single enantiomers (R) and (S) are disclosed useful in the treatment or prevention of symptoms and disorders such as pain and inflammation associated with the bradykinin B1 pathway.
