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10078-27-0

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10078-27-0 Usage

Chemical Properties

White Crystalline Solid

Uses

Different sources of media describe the Uses of 10078-27-0 differently. You can refer to the following data:
1. A metabolite of Prochlorperazine
2. A metabolite of Prochlorperazine.

Check Digit Verification of cas no

The CAS Registry Mumber 10078-27-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,0,7 and 8 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 10078-27:
(7*1)+(6*0)+(5*0)+(4*7)+(3*8)+(2*2)+(1*7)=70
70 % 10 = 0
So 10078-27-0 is a valid CAS Registry Number.
InChI:InChI=1/C20H24ClN3OS/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)26(25)20-8-7-16(21)15-18(20)24/h2-3,5-8,15H,4,9-14H2,1H3

10078-27-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine 5-oxide

1.2 Other means of identification

Product number -
Other names 2-Chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine 5-Oxide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10078-27-0 SDS

10078-27-0Synthetic route

prochlorperazine
58-38-8

prochlorperazine

Prochlorperazine sulfoxide
10078-27-0

Prochlorperazine sulfoxide

Conditions
ConditionsYield
With hydrogenchloride; sodium nitrite In water for 2h;72%
With dihydrogen peroxide; acetic acid In methanol for 24h; Heating;
With hydrogenchloride; potassium iodate; sodium hydroxide In water at 25℃; for 0.166667h;
4-<3-(2-chloro-10-phenothiazinyl)propyl>-1-methylpiperazine acetate

4-<3-(2-chloro-10-phenothiazinyl)propyl>-1-methylpiperazine acetate

Prochlorperazine sulfoxide
10078-27-0

Prochlorperazine sulfoxide

Conditions
ConditionsYield
With dihydrogen peroxide; acetic acid In methanol for 17h; Heating;37%
Prochlorperazine sulfoxide
10078-27-0

Prochlorperazine sulfoxide

maleic acid
110-16-7

maleic acid

prochlorperazine sulfoxide maleate

prochlorperazine sulfoxide maleate

Conditions
ConditionsYield
In ethanol Heating;67%

10078-27-0Upstream product

10078-27-0Downstream Products

10078-27-0Relevant articles and documents

Sensitive spectrophotometric method for determination of some phenothiazine drugs

Upadhyay, Kanchan,Asthana, Anupama,Tamrakar, Raunak Kumar

, p. 7481 - 7495 (2015)

A new simple and sensitive spectrophotometric method for some phenothiazine derivatives has been developed. The proposed method is based on the reaction of phenothiazine derivatives promethazine hydrochloride, chlorpromazine hydrochloride, triflupromazine hydrochloride, prochlorperazine, and trifluoperazine with potassium iodate followed by reaction of liberated iodine with leuco crystal violet (LCV) and measurement of the color of the oxidized LCV at 598 nm. The method showed a good linearity in the ranges 0.05-4.0, 0.02-2.0, 0.05-5.0, 0.1-8.0, and 0.05-2.0 μg mL-1 respectively. The optimum conditions and other analytical parameters were evaluated. The proposed methods have been applied successfully to the analysis of phenothiazine derivatives in pure form and in their dosage forms, and no interference was observed from common excipients present in pharmaceutical formulations.

Convenient oxidation of phenothiazine salts to their sulfoxides with aqueous nitrous acid

Owens,Juenge,Poklis

, p. 334 - 336 (2007/10/02)

A simple method is reported for the preparation of gram quantities of phenothiazine sulfoxides by aqueous nitrous acid oxidation of phenothiazines at room temperature. The chiral levomepromazine gave rise to diastereoisomeric products analogous to those reported for thioridazine sulfoxidation.

Synthesis of phenothiazines. VIII. 10-piperazinylalkyl dirivatives of 2-chloro- and 2-trifluoromethvlphenothiazine [1.]

ANDERSON

, p. 937 - 942 (2007/10/04)

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