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58-38-8

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58-38-8 Usage

Uses

Different sources of media describe the Uses of 58-38-8 differently. You can refer to the following data:
1. antiemetic, antipsychotic, treatment of vertigo
2. Prochlorperazine is antiemetic, antipsychotic; used in treatment of vertigo.

Definition

ChEBI: A member of the class of phenothiazines that is 10H-phenothiazine having a chloro substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position.

Brand name

Compazine (GlaxoSmithKline).

Clinical Use

Nausea and vomiting Labyrinthine disorders Psychoses Severe anxiety

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental teratogenic and reproductive effects. Human systemic effects by ingestion: headache, blood pressure elevation. Implicated in aplastic anemia. When heated to decomposition it emits very toxic fumes of SOx, NOx, and Cl-.

Veterinary Drugs and Treatments

Prochlorperazine as a single agent is used in dogs and cats as an antiemetic. The only approved products for animals are combination products containing prochlorperazine, isopropamide, with or without neomycin (Darbazine?, Neo-Darbazine?—SKB Labs) which are no longer marketed in the USA. The approved indications for these products include: vomiting, non-specific gastroenteritis, drug induced diarrhea, infectious diarrhea, spastic colitis, and motion sickness in dogs and cats (injectable product only).

Drug interactions

Potentially hazardous interactions with other drugs Anaesthetics: enhanced hypotensive effect. Analgesics: increased risk of convulsions with tramadol; enhanced hypotensive and sedative effects with opioids; increased risk of ventricular arrhythmias with methadone. Anti-arrhythmics increased risk of ventricular arrhythmias with anti-arrhythmics that prolong the QT interval, e.g. procainamide, disopyramide, dronedarone and amiodarone - avoid with amiodarone and dronedarone. Antibacterials: increased risk of ventricular arrhythmias with delamanid and moxifloxacin - avoid. Antidepressants: increase concentrations and additive antimuscarinic effects, notably with tricyclics; increased risk of ventricular arrhythmias with citalopram and escitalopram - avoid; increased risk of convulsions with vortioxetine. Antiepileptics: antagonised (convulsive threshold lowered). Antimalarials: avoid with artemether/lumefantrine and piperaquine with artenimol. Antipsychotics: increased risk of ventricular arrhythmias with droperidol and pimozide - avoid; increased risk of ventricular arrhythmias with risperidone. Antivirals: concentration possibly increased with ritonavir; increased risk of ventricular arrhythmias with saquinavir - avoid. Anxiolytics and hypnotics: increased sedative effects. Atomoxetine: increased risk of ventricular arrhythmias. Beta-blockers: enhanced hypotensive effect; increased risk of ventricular arrhythmias with sotalol. Cytotoxics: increased risk of ventricular arrhythmias with arsenic trioxide. Desferrioxamine: avoid concomitant use. Diuretics: enhanced hypotensive effect. Lithium: increased risk of extrapyramidal side effects and possibly neurotoxicity. Pentamidine: increased risk of ventricular arrhythmias.

Metabolism

Prochlorperazine undergoes extensive first pass metabolism in the gut wall. It is also extensively metabolised in the liver and is excreted in the urine and bile. The metabolites are inactive.

Check Digit Verification of cas no

The CAS Registry Mumber 58-38-8 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 8 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 58-38:
(4*5)+(3*8)+(2*3)+(1*8)=58
58 % 10 = 8
So 58-38-8 is a valid CAS Registry Number.
InChI:InChI=1/C20H24ClN3S/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24/h2-3,5-8,15H,4,9-14H2,1H3

58-38-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name prochlorperazine

1.2 Other means of identification

Product number -
Other names RP-6140

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:58-38-8 SDS

58-38-8Relevant articles and documents

A preparation method of the third chlorine pulls qin

-

Paragraph 0026; 0028; 0031, (2018/10/11)

The invention discloses a method for preparing the third chlorine pulls qin, has changed the existing method of the reaction sequence, the first to use 1 - bromo - 3 - chloro propane and 2 - chloro phenothiazine reaction, further with the third chlorine pulls qin N - methyl piperazine is generated by the reaction. This invention discloses technology can not complete reaction lead to reaction the cost is high, and has a gene toxic impurities to make the final purity of the product is difficult to achieve the medical-grade technical defect.

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