100784-90-5

Usage

Molecular structure

1H-Pyrrole-2-carboxylic acid, 3-(4-methoxyphenyl)-5-phenyl-, ethyl ester has a pyrrole core with a carboxylic acid group at the 2-position, connected to a 3-(4-methoxyphenyl)-5-phenyl side chain.

Classification

It is an ethyl ester compound.

Usage

Commonly used in organic synthesis and pharmaceutical research as a precursor for the preparation of various bioactive compounds.

Potential applications

The compound has potential applications in drug discovery and development, particularly in the design and synthesis of novel pharmaceutical agents with potential therapeutic properties.

Value in research

Its chemical structure and properties make it a valuable tool for medicinal chemistry and drug design studies.

Upstream product

• 100784-82-5 3-(4-Methoxy-phenyl)-5-phenyl-pyrrole-1,2-dicarboxylic acid diethyl ester 
• 623-33-6 glycine ethyl ester hydrochloride 
• 959-33-1 3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one 
• 1279698-12-2 ethyl 3-(4-methoxyphenyl)-2-nitro-5-oxo-5-phenylpentanoate 
• 22252-15-9 trans-4-methoxychalcone 
• 1253042-08-8 ethyl 3-(4-methoxyphenyl)-2,5-dioxo-5-phenylpentanoate 
• 75703-50-3 diethyl 3-(p-methoxyphenyl)-5-phenyl-3,4-dihydro-2H-pyrrole-2,2-dicarboxylate 
• 3179-10-0 (E)-1-methoxy-4-(2-nitrovinyl)benzene 
• 40682-54-0 ethyl N-benzylideneglycinate 

Relevant academic research and scientific papers

One-pot synthesis of pyrrole-2-carboxylates and -carboxamides via an electrocyclization/oxidation sequence

An electrocyclic ring closure is the key step of an efficient one-pot method for the synthesis of pyrrole-2-carboxylates and -carboxamides from chalcones and glycine esters or amides. The 3,4-dihydro-2H-pyrrole intermediates generated in situ are oxidized

DBU-promoted tandem Michael-addition/cyclization for the synthesis of polysubstituted pyrroles

An efficient and transition-metal-free method for the synthesis of the structurally diversified pyrroles is described. Various α,β-unsaturated ynones reacted with N-substituted ethyl glycine ethyl ester hydrochlorides in the presence of DBU to form the co

A solvent-free synthesis of ethyl 3,5-diaryl-1H-pyrrole-2-carboxylates via triethylphosphite mediated reductive cyclization of ethyl 2-nitro-5-oxo-3,5- diarylpentanoates under microwave irradiation

Ethyl 3,5-diaryl-1H-pyrrole-2-carboxylates have been synthesized in good yields from ethyl 2-nitro-5-oxo-3,5-diarylpentanoates by treatment with triethylphosphite under microwave irradiation. The integrity of the mechanism proposed has been augmented by

NEW HISTONE DEACETYLASE INHIBITORS BASED SIMULTANEOUSLY ON TRISUBSTITUTED 1H-PYRROLES AND AROMATIC AND HETEROAROMATIC SPACERS

The present invention refers to compounds derived from trisubstituted 1H-pyrrole rings and aromatic rings, which have the following formula (I): wherein: R1 and R2 represent, independently, an optionally substituted C6-Cs

NEW HISTONE DEACETYLASE INHIBITORS BASED SIMULTANEOUSLY ON TRISUBSTITUTED 1H-PYRROLES AND AROMATIC AND HETEROAROMATIC SPACERS

The present invention refers to compounds derived from trisubstituted 1H- pyrrole rings and aromatic rings, which have the following formula (I): wherein: R1 and R2 represent, independently, an optionally substituted C6-C

Formation of γ-oxoacids and 1 H-pyrrol-2(5 H)-ones from α,β-unsaturated ketones and ethyl nitroacetate

Michael addition of ethyl nitroacetate on α,β-unsaturated ketones followed by Nef oxidation under hydrolytic conditions yields γ-oxoacids instead of the corresponding α,δ-dioxoesters. A concerted decarboxylation step is proposed on the basis of computational results. Finally, conversion of the γ-ketoacids thus prepared into 1H-pyrrol-2(5H)-ones by reaction with primary amines under Paal-Knorr conditions is also reported.

A new synthesis of 3,5-diaryl-pyrrole-2-carboxylic acids and esters

A new two-step synthesis of pyrrole-2-carboxylic acids, steps via 1,3 dipolar cycloaddition of azomethine ylides to nitro-styrenes and oxidation of the resulting pyrrolidines with alkaline hydrogen peroxide is described. The oxidation of cycloadducts 3 by the means of MnO2 under different conditions also has been examined. (C) 2000 Elsevier Science Ltd.

The Synthesis and Chemistry of Azolenines. Part 4. Preparation and Rearrangement of some 3,5-Diaryl-2H-pyrrole-2,2-dicarboxylic Esters

Oxidation of diethyl 3,5-diaryl-3,4-dihydro-2H-pyrrole-2,2-dicarboxylates (3) with chloranil in refluxing xylene gives not the 3,5-diaryl-2H-pyrrole-2,2-dicarboxylates (4) as reported by an earlier group, but instead the rearranged, isomeric, 1H-pyrrole-1,2-dicarboxylates (5). 2H-Pyrroles (4) may be obtained from the dihydropyrroles (3) using DDQ in benzene at room temperature; they rearrange to the isomers (5) in boiling xylene via an acyl -sigmatropic shift from carbon to nitrogen, a novel process in the 2H-pyrrole series.Thermal analyses indicate that the rearrangement is concerted with negligible charge separation in the transition state.Other novel 3,5-diaryl-1H-pyrrole-2-carboxylic acid derivatives are described.