1279698-12-2

Upstream product

• 626-35-7 nitroacetic acid ethyl ester 
• 22252-15-9 trans-4-methoxychalcone 
• 959-33-1 3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one 

Downstream Products

• 1253042-08-8 ethyl 3-(4-methoxyphenyl)-2,5-dioxo-5-phenylpentanoate 
• 3261-90-3 2-(4-methoxyphenyl)-4-oxo-4-phenylbutanoic acid 
• 100784-90-5 ethyl 3-(4-methoxyphenyl)-5-phenyl-1H-pyrrole-2-carboxylate 

Relevant academic research and scientific papers

A solvent-free synthesis of ethyl 3,5-diaryl-1H-pyrrole-2-carboxylates via triethylphosphite mediated reductive cyclization of ethyl 2-nitro-5-oxo-3,5- diarylpentanoates under microwave irradiation

Ethyl 3,5-diaryl-1H-pyrrole-2-carboxylates have been synthesized in good yields from ethyl 2-nitro-5-oxo-3,5-diarylpentanoates by treatment with triethylphosphite under microwave irradiation. The integrity of the mechanism proposed has been augmented by

NEW HISTONE DEACETYLASE INHIBITORS BASED SIMULTANEOUSLY ON TRISUBSTITUTED 1H-PYRROLES AND AROMATIC AND HETEROAROMATIC SPACERS

The present invention refers to compounds derived from trisubstituted 1H-pyrrole rings and aromatic rings, which have the following formula (I): wherein: R1 and R2 represent, independently, an optionally substituted C6-Cs

NEW HISTONE DEACETYLASE INHIBITORS BASED SIMULTANEOUSLY ON TRISUBSTITUTED 1H-PYRROLES AND AROMATIC AND HETEROAROMATIC SPACERS

The present invention refers to compounds derived from trisubstituted 1H- pyrrole rings and aromatic rings, which have the following formula (I): wherein: R1 and R2 represent, independently, an optionally substituted C6-C

Formation of γ-oxoacids and 1 H-pyrrol-2(5 H)-ones from α,β-unsaturated ketones and ethyl nitroacetate

Michael addition of ethyl nitroacetate on α,β-unsaturated ketones followed by Nef oxidation under hydrolytic conditions yields γ-oxoacids instead of the corresponding α,δ-dioxoesters. A concerted decarboxylation step is proposed on the basis of computational results. Finally, conversion of the γ-ketoacids thus prepared into 1H-pyrrol-2(5H)-ones by reaction with primary amines under Paal-Knorr conditions is also reported.