1007841-60-2Relevant academic research and scientific papers
Asymmetric Nazarov Cyclizations Catalyzed by Chiral-at-Metal Complexes
Mietke, Thomas,Cruchter, Thomas,Larionov, Vladimir A.,Faber, Tabea,Harms, Klaus,Meggers, Eric
, p. 2093 - 2100 (2018)
The application of Lewis acidic chiral-at-metal complexes of iridium(III) and rhodium(III) as catalysts for the asymmetric polarized Nazarov cyclization of dihydropyran- and indole-functionalized α-unsaturated β-ketoesters is reported (overall 24 examples). For both substrate classes, catalyst loadings of 2 mol% were found to be sufficient for achieving high yields and high stereoselectivities. The cyclized dihydropyran products were isolated in 85–98% yield, with 89%–>99% ee, and trans/cis ratios of 15:1–50:1 (9 examples). The cyclized indole products were typically isolated in more than 70% yield and in up to 93% yield, typically with more than 90% ee and in up to 97% ee, and trans/cis ratios of 12:1–28:1 (15 examples). (Figure presented.).
Polarizing the nazarov cyclization: The impact of dienone substitution pattern on reactivity and selectivity
He, Wei,Herrick, Ildiko R.,Atesin, Tulay A.,Caruana, Patrick A.,Kellenberger, Colleen A.,Frontier, Alison J.
, p. 1003 - 1011 (2008/10/09)
The impact of dienone substitution on the Nazarov cyclization has been examined in detail. Substrates bearing different substituents at each of four positions on the dienone backbone were systematically probed in order to identify trends leading to higher
