1008-35-1

Basic information

• Product Name: tetrahydropterin
• Synonyms: tetrahydropterin;2-Amino-5,6,7,8-tetrahydro-4(1H)-pteridinone;2-Amino-5,6,7,8-tetrahydro-4-pteridinol;2-Amino-5,6,7,8-tetrahydropteridin-4(3H)-one;5,6,7,8-Tetrahydropterin
• CAS NO: 1008-35-1
• Molecular Formula: C6H9 N5 O
• Molecular Weight: 167.17
• Mol File: 1008-35-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 355.9°Cat760mmHg
• Flash Point: 169.1°C
• Appearance: /
• Density: 1.96g/cm³
• Vapor Pressure: 3.02E-05mmHg at 25°C
• Refractive Index: 1.917
• CAS DataBase Reference: tetrahydropterin(CAS DataBase Reference)
• NIST Chemistry Reference: tetrahydropterin(1008-35-1)
• EPA Substance Registry System: tetrahydropterin(1008-35-1)

Safety Data

• Hazardous Substances Data: 1008-35-1(Hazardous Substances Data)

Usage

General Description

Tetrahydropterin is a chemical compound that is essential for the synthesis of neurotransmitters like dopamine, serotonin, and norepinephrine. It plays a crucial role in the metabolism of amino acids and the production of various crucial molecules in the body. Tetrahydropterin is a co-factor for the enzyme tyrosine hydroxylase, which is involved in the production of dopamine, and tryptophan hydroxylase, which is involved in the production of serotonin. It is also involved in the synthesis of nitric oxide, which plays a role in regulating blood pressure and neurotransmission. Tetrahydropterin is a critical component in many physiological processes, and its deficiency can lead to neurodevelopmental and neuropsychiatric disorders.

InChI:InChI=1/C6H9N5O/c7-6-10-4-3(5(12)11-6)8-1-2-9-4/h8H,1-2H2,(H4,7,9,10,11,12)

Upstream product

• 2236-60-4 2-aminopteridin-4(3H)-one 

Downstream Products

• 17838-80-1 7,8-dihydropterin 
• 2236-60-4 2-aminopteridin-4(1H)-one 

Relevant articles and documents

Oxidation of tetrahydropterins by azide radical and the spectra of trihydropterin radicals

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Determination of Pterins in Biological Samples by Liquid Chromatography/Electrochemistry with a Dual-Electrode Detector

The pterins are a family of compounds that are currently of great interest in medicine and biology.Biopterin, in its reduced form, serves as the cofactor to the enzyme which catalyze the rate-limiting reactions in the biosynthesis of the catecholamines and serotonin.As such, it may serve a role in the regulation of the neurotransmitters.Abnormal pterin concentrations have been observed in the urine and serum of patiens with several diseases.No currently available analytical method is totally satisfactory for the determination of pterins in biological samples.They lack either specificity or the ability to detect both the oxidzed and reduced forms of the pterins.Liquid chromatography/electrochemistry (LCEC) using a dual-electrode detector can overcome both of these problems.A method has been developed that is capable of determining several pterin species and their various oxidation states in biological samples.The dual-electrode detector used in a parallel-adjacent configuration is also capable of enhancing peak identity assignments and selectively determining easily oxidized compounds in the presence of harder to oxidize compounds.