1008-35-1

Usage

Uses

Used in Pharmaceutical Industry:
Tetrahydropterin is used as a therapeutic agent for the treatment of neurodevelopmental and neuropsychiatric disorders caused by its deficiency. Its role in neurotransmitter synthesis makes it a potential candidate for managing conditions related to neurotransmitter imbalances.
Used in Research Applications:
Tetrahydropterin is utilized as a research tool in studying the mechanisms of neurotransmitter synthesis, enzyme functions, and the role of nitric oxide in physiological processes. It aids in understanding the underlying causes of various neurological and psychiatric conditions and contributes to the development of targeted therapies.
Used in Diagnostic Applications:
Tetrahydropterin is employed as a biomarker in the diagnosis of certain genetic disorders, such as phenylketonuria (PKU), where its levels can indicate the severity of the condition and the effectiveness of treatment.
Used in Nutritional Supplements:
Tetrahydropterin is used as a dietary supplement to support neurotransmitter synthesis and maintain optimal brain function. It may be particularly beneficial for individuals with deficiencies or those at risk of developing neurodevelopmental and neuropsychiatric disorders.

InChI:InChI=1/C6H9N5O/c7-6-10-4-3(5(12)11-6)8-1-2-9-4/h8H,1-2H2,(H4,7,9,10,11,12)

Upstream product

• 2236-60-4 2-aminopteridin-4(3H)-one 

Downstream Products

• 17838-80-1 7,8-dihydropterin 
• 2236-60-4 2-aminopteridin-4(1H)-one 

Relevant academic research and scientific papers

130. Reaction of 5,6,7,8-Tetrahydropterin with Iron(III) Acetylacetonate. Detection of Radical Cations by Electrospray Ionization Mass Spectrometry

The experimental conditions developed for the detection of rather stable radical cations in solution by electrospray-ionization mass spectrometry (ESI-MS) of a Fe(II) complex of 2-amino-5,6,7,8-tetrahydro-5-methylpteridin-4(3H)-one (1c) are used to observe the formation of the more unstable radical cations formed from 2-amino-5,6,7,8-tetrahydropteridin-4(3H)-one (1a) and tris(pentane-2,4-dionato)iron(III) (; 4) and to monitor their oxidation to the corresponding p-quinonoid dihydropterin complexes.These results contribute to the understanding of the important role played by 6β-5,6,7,8-tetrahydro-L-biopterin (1b; a homologue of 1a) together with iron as constituent of some cofactors.The complexes obtained from 1a and iron may be considered, e.g. as a model of the cofactor of the phenylalanine hydroxylase.Moreover, we describe an improved synthesis of 1c.

Determination of Pterins in Biological Samples by Liquid Chromatography/Electrochemistry with a Dual-Electrode Detector

The pterins are a family of compounds that are currently of great interest in medicine and biology.Biopterin, in its reduced form, serves as the cofactor to the enzyme which catalyze the rate-limiting reactions in the biosynthesis of the catecholamines and serotonin.As such, it may serve a role in the regulation of the neurotransmitters.Abnormal pterin concentrations have been observed in the urine and serum of patiens with several diseases.No currently available analytical method is totally satisfactory for the determination of pterins in biological samples.They lack either specificity or the ability to detect both the oxidzed and reduced forms of the pterins.Liquid chromatography/electrochemistry (LCEC) using a dual-electrode detector can overcome both of these problems.A method has been developed that is capable of determining several pterin species and their various oxidation states in biological samples.The dual-electrode detector used in a parallel-adjacent configuration is also capable of enhancing peak identity assignments and selectively determining easily oxidized compounds in the presence of harder to oxidize compounds.