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17838-80-1

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17838-80-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 17838-80-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,8,3 and 8 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 17838-80:
(7*1)+(6*7)+(5*8)+(4*3)+(3*8)+(2*8)+(1*0)=141
141 % 10 = 1
So 17838-80-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H7N5O/c7-6-10-4-3(5(12)11-6)8-1-2-9-4/h1H,2H2,(H4,7,9,10,11,12)

17838-80-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 7,8-dihydropterin

1.2 Other means of identification

Product number -
Other names dihydropterin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:17838-80-1 SDS

17838-80-1Downstream Products

17838-80-1Relevant articles and documents

Transformation of 6-tetrahydrobiopterin in aqueous solutions under UV-irradiation

Telegina, Taisiya A.,Lyudnikova, Tamara A.,Buglak, Andrey A.,Vechtomova, Yulia L.,Biryukov, Mikhail V.,Demin, Vladimir V.,Kritsky, Mikhail S.

, p. 155 - 162 (2017/09/06)

Melanogenesis disturbance leads to several pathologies, including vitiligo disease. Ultraviolet (UV) narrowband phototherapy (308 or 311 nm) is used in treating vitiligo; however, the mechanism of phototherapy is not yet understood. Vitiligo is accompanied by three-fivefold increased de-novo synthesis of (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (H4Bip), its excess and its further oxidation can be considered as significant factors in the pathogenesis of vitiligo. (H4Bip), as the phenylalanine 4-hydroxylase coenzyme, catalyzes the oxidation of phenylalanine to tyrosine (a melanin precursor). In this context, photo-transformation of H4Bip in aqueous buffer solutions has been studied. HPLC–MS/MS has demonstrated that pterin products of H4Bip autoxidation (7,8-dihydropterin (H2Ptr), dihydroxanthopterin and pterin) predominate over biopterin products (7,8-dihydrobiopterin (H2Bip) and biopterin). We have shown that UV irradiation accelerates the autoxidation while the products of oxidative degradation of H4Bip act as photosensitizers. The distinctive feature of photooxidation of H4Bip from autoxidation is the formation of dihydropterin (Н2Ptr)2 and dihydrobiopterin (Н2Bip)2 dimers. By means of HPLC–MS/MS it was found that formation of dihydropterin dimers is the predominant process. The signal of molecular ion of the dimer (Н2Ptr)2 (m/z = 331) was almost a thousand times higher than the signal of (Н2Bip)2 (m/z = 479). The key point of the dimerization is photoexcitation (at 310–320 nm) of the intermolecular complex (qH2Ptr-Н2Ptr) generated in dark. As a result of the photoreaction azacyclobutane dimers have been formed. In the case of alternation of dark and light intervals H4Bip converted into dimers with 96 % yield. The data obtained are discussed in the context of UV-B narrowband vitiligo phototherapy.

Determination of Pterins in Biological Samples by Liquid Chromatography/Electrochemistry with a Dual-Electrode Detector

Lunte, Craig E.,Kissinger, Peter T.

, p. 1458 - 1462 (2007/10/02)

The pterins are a family of compounds that are currently of great interest in medicine and biology.Biopterin, in its reduced form, serves as the cofactor to the enzyme which catalyze the rate-limiting reactions in the biosynthesis of the catecholamines and serotonin.As such, it may serve a role in the regulation of the neurotransmitters.Abnormal pterin concentrations have been observed in the urine and serum of patiens with several diseases.No currently available analytical method is totally satisfactory for the determination of pterins in biological samples.They lack either specificity or the ability to detect both the oxidzed and reduced forms of the pterins.Liquid chromatography/electrochemistry (LCEC) using a dual-electrode detector can overcome both of these problems.A method has been developed that is capable of determining several pterin species and their various oxidation states in biological samples.The dual-electrode detector used in a parallel-adjacent configuration is also capable of enhancing peak identity assignments and selectively determining easily oxidized compounds in the presence of harder to oxidize compounds.

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