100800-85-9Relevant academic research and scientific papers
Transamidation for the Synthesis of Primary Amides at Room Temperature
Chen, Jiajia,Lee, Sunwoo,Xia, Yuanzhi
supporting information, (2020/05/05)
Various primary amides have been synthesized using the transamidation of various tertiary amides under metal-free and mild reaction conditions. When (NH4)2CO3 reacts with a tertiary amide bearing an N-electron-withdrawing substituent, such as sulfonyl and diacyl, in DMSO at 25 °C, the desired primary amide product is formed in good yield with good funcctional group tolerance. In addition, N-tosylated lactam derivatives afforded their corresponding N-tosylamido alkyl amide products via a ring opening reaction.
SYNTHESIS OF ALIPHATIC AMINES RELATED TO MONODANSYLCADAVERINE VIA THE OXIDATIVE REARRANGEMENT OF ALIPHATIC AMIDES WITH PHENYL IODOSYL BIS(TRIFLUOROACETATE)
Pavlidis, V. H.,Chan, E. D.,Pennington, L.,McParland, M.,Whitehead, M.
, p. 1615 - 1624 (2007/10/02)
A series of aliphatic primary amides have been oxidatively rearranged to primary amines with phenyl iodosyl(trifluoroacetate).Sulfonamide groups on the substrates have not been affected.
