60-32-2 Usage
Description
6-aminocaproic acid (Brand name: Amicar) is a kind of synthetic derivative of lysine. Since it is a analogue of amino acid lysine, it can act as the inhibitor for enzymes that need to bind to that particular lysine residue, e.g. the proteolytic enzyme such as plasmin, which is responsible for fibrinolysis. Therefore, it has anti-fibrinolytic activity. It also competitively inhibits activation of plasminogen, thereby reducing conversion of plasminogen to plasmin. Based on this property, it can be used for the treatment of acute bleeding due to elevated fibrinolytic activity in many clinical situations. It can also indicated by FDA for the prevention of recurrent hemorrhage in patients of traumatic hyphema. It may also act as a prophylactic against the vascular disease due to its inhibitory effect on the formation of lipoprotein which is the risk factor of vascular disease.
References
https://pubchem.ncbi.nlm.nih.gov/compound/6-aminohexanoic_acid#section=Pharmacology-and-Biochemistry
https://en.wikipedia.org/wiki/Aminocaproic_acid
Chemical Properties
white crystalline powder. Leaf crystals were obtained from ether. Odorless, bitter taste. Melting point 202 ~ 207 ℃ (decomposition). Soluble in water, slightly soluble in methanol, insoluble in ethanol, ether and chloroform.
Originator
Epsilon,Roche,W. Germany,1962
Uses
Different sources of media describe the Uses of 60-32-2 differently. You can refer to the following data:
1. EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl2, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.
2. 6-Aminohexanoic Acid is a reagent commonly used for the extraction of aldehydes from reaction mixtures. 6-Aminohexanoic Acid has also been shown to improve solubilization of membrane proteins in elect
rophoresis. Studies suggest that 6-Aminohexanoic Acid inhibits the activation of the first component of the complement system.
Definition
ChEBI: 6-aminohexanoic acid is an epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator. It has a role as an antifibrinolytic drug, a hematologic agent and a metabolite. It is an epsilon-amino acid and an omega-amino fatty acid. It derives from a hexanoic acid. It is a conjugate acid of a 6-aminohexanoate. It is a tautomer of a 6-aminohexanoic acid zwitterion.
Application
6-Aminohexanoic acid was used as a biochemical reagent. It is also used as a hemostatic agent. 6-aminocaproic acid has a significant effect on some severe bleeding caused by increased fibrinolytic activity. It is suitable for oozing or local bleeding during various surgical operations. 6-aminocaproic acid is used for hemoptysis, gastrointestinal bleeding and bleeding disorders in obstetrics and gynecology.6-Aminocaproic acid is an anti-fibrinolytic drug with a similar chemical structure to lysine. It can qualitatively inhibit the binding of plasminogen to fibrin and prevent its activation, thereby inhibiting fibrinolysis and achieving hemostasis. Aminocaproic acid is a monoaminocarboxylic acid, which can inhibit the conversion of plasminogen into plasmin and its binding to fibrin. For severe bleeding caused by hyperfibrinolysis caused by increased activation of plasminogen, can have therapeutic effect.
Preparation
6-aminocaproic acid is obtained by hydrolysis of 6-(N-benzoylamino)capronitrile in the presence of hydrochloric acid, or by hydrolysis of caprolactam in the presence of hydrochloric acid, and then treated with ammonium hydroxide.
Manufacturing Process
5 kg of caprolactam were heated with 40 liters of water in a pressure vessel at 250°C for a period of four hours. These quantities of reactants correspond
to a water:lactam molecular ratio of 50:1. After cooling, the small quantity of
the nonsoluble substance that is formed is filtered off, and the filtrate is
evaporated as far as possible. The resulting concentrate is mixed with three
times its volume of strong alcohol, thereby causing the desired product,
epsilon-aminocaproic acid (6-aminohexanoic acid), to crystallize out. After
separating the crystalline product thus obtained, a further quantity of epsilonaminocaproic
acid can be obtained from the mother liquid if desired.
Brand name
Amicar (Xanodyne).
General Description
6-Aminocaproic acid is a synthetic inhibitor of fibrinolysis and is utilized for the control of excessive bleeding in patients with amegakaryocytic thrombocytopenia. It also is a protease inhibitor that displays anticancer activity but is limited by cytotoxicity.
Biochem/physiol Actions
Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B.
Mechanism of action
Because binding of plasminogen or plasmin to fibrinogen or fibrin is mediated by lysine
groups that are part of the structures of fibrin and fibrinogen, aminocaproic acid, which is
a structural analog of lysine that only differs in that it has one less amino group, acts as a
competitive inhibitor for binding of plasmin(ogen) to fibrin. Aminocaproic acid shifts the
homeostatic balance on the side of coagulation, thus restoring fibrinolytic mechanism
activity. Aminocaproic acid, which is not a procoagulant, such as those used during surgical
intervention and various pathological conditions, is accompanied by an elevation in fibrinolytic
activity of blood and tissue. It is used to stop bleeding.
Safety Profile
Moderately toxic by intravenous route. Human systemic effects by ingestion: changes in tubules (includmg acute renal failure, acute tubular necrosis), hematuria, and increased body temperature. Experimental reproductive effects. An eye irritant. When heated to decomposition it emits toxic fumes such as NOx,.
Synthesis
Aminocaproic acid (24.4.1) is synthesized by hydrolyzing ε -caprolactam
at high temperature.
Veterinary Drugs and Treatments
Aminocaproic acid has been used as a treatment to degenerative
myelopathy (seen primarily in German shepherds), but no controlled
studies documenting its efficacy were located. There is interest
in evaluating aminocaproic acid for adjunctive treatment of
thrombocytopenia in dogs, but efficacy and safety for this purpose
remains to be investigated. In humans, it is primarily used for treating
hyperfibrinolysis-induced hemorrhage.
Check Digit Verification of cas no
The CAS Registry Mumber 60-32-2 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 0 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 60-32:
(4*6)+(3*0)+(2*3)+(1*2)=32
32 % 10 = 2
So 60-32-2 is a valid CAS Registry Number.
InChI:InChI=1/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)/p-1
60-32-2Relevant articles and documents
-
Yumoto,Ogata
, p. 91 (1958)
-
The pharmacophore of a peptoid VEGF receptor 2 antagonist includes both side chain and main chain residues
Udugamasooriya, D. Gomika,Dunham, Geoff,Ritchie, Caroline,Brekken, Rolf A.,Kodadek, Thomas
, p. 5892 - 5894 (2008)
Here we identify the pharmacophore in a peptoid that antagonizes Vascular Endothelial Growth Factor Receptor-2 (VEGFR2) in vitro and in vivo. Only three of the side chains in the peptoid are required for activity. Surprisingly, however, main chain atoms also form critical interactions with the receptor.
-
Wiloth
, p. 37 (1958)
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Activation of Water at the Active-Site Cavity of Zinc Phthalocyanine with Tris(pentafluorophenyl)borane
Ikeuchi, Takuro,Kudo, Ryota,Yoshii, Tatsuya,Kobayashi, Nagao,Kitazawa, Yu,Kimura, Mutsumi
, p. 622 - 625 (2020)
Activation of water bound with Zn2+ has attracted much attention as an artificial model of natural enzymes. Despite many attempts, water activation accompanied with a change in the coordination geometry of Zn2+ in complexes remains a challenge. In this study, we discover a new structure that is composed of partially protonated zinc phthalocyanine (ZnPc), hydroxide ion, and tris(pentafluorophenyl)borane (TPFB). The coordination of TPFB with water bounded with ZnPc results in the dissociation of water, and the dissociated proton from water moves to one nitrogen atom of the phthalocyanine ring through the intramolecular proton transfer. On the basis of this reaction, the coordination geometry transforms from a five-coordinated to a distorted tetrahedral species. The Zn2+-bound hydroxide nucleophile in the ZnPc-TPFB complex attacks amide of ε-caprolactam to produce hydrolyzed 6-aminohexanoic acid in toluene.
Preparation method of 6-aminocaproic acid
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Paragraph 0027-0036, (2021/03/18)
The invention discloses a preparation method of 6-aminocaproic acid, which comprises the following steps: by using caprolactam as a raw material, carrying out alkaline hydrolysis, neutralization treatment, desalination treatment and refining treatment to obtain the 6-aminocaproic acid, wherein the alkaline hydrolysis is carried out on caprolactam, sodium hydroxide and water at a certain temperature and under a certain pressure, a certain temperature is 115-125 DEG C, a certain pressure is 0.15-0.3 MPa, and the reaction time of alkaline hydrolysis does not exceed 1.5 hours. According to the alkaline hydrolysis method disclosed by the invention, the hydrolysis time is shortened through pressurization, so that the generation of by-products can be effectively inhibited under the condition of ensuring complete hydrolysis, and therefore, the alkaline hydrolysis method not only has relatively high reaction yield, but also has relatively high product purity.
New cationic heptamethinecyanine-graphene hybrid materials
Prousis, Kyriakos C.,Canton-Vitoria, Ruben,Pagona, Georgia,Goulielmaki, Maria,Zoumpourlis, Vassilis,Tagmatarchis, Nikos,Calogeropoulou, Theodora
, (2019/12/27)
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