100802-96-8

Basic information

• Product Name: Chloromethyl-phosphonic acid mono-[(2R,3R,3aR,9aR)-2-(6-benzoylamino-purin-9-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl] ester
• CAS NO: 100802-96-8
• Molecular Weight: 726.314
• Mol File: 100802-96-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Chloromethyl-phosphonic acid mono-[(2R,3R,3aR,9aR)-2-(6-benzoylamino-purin-9-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl] ester(CAS DataBase Reference)
• NIST Chemistry Reference: Chloromethyl-phosphonic acid mono-[(2R,3R,3aR,9aR)-2-(6-benzoylamino-purin-9-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl] ester(100802-96-8)
• EPA Substance Registry System: Chloromethyl-phosphonic acid mono-[(2R,3R,3aR,9aR)-2-(6-benzoylamino-purin-9-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl] ester(100802-96-8)

Safety Data

• Hazardous Substances Data: 100802-96-8(Hazardous Substances Data)

Upstream product

• 79154-57-7 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N₆-benzoyladenosine 

Downstream Products

• 100778-90-3 Chloromethyl-phosphonic acid mono-[(2R,3R,4R,5R)-2-(6-benzoylamino-purin-9-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl] ester 

Relevant articles and documents

PHOSPHONYLMETHYL ANALOGUES OF RIBONUCLEOSIDE 2',3'-CYCLIC PHOSPHATES AND 2'(3')-NUCLEOTIDE METHYL ESTERS: SYNTHESIS AND PROPERTIES

2'(3')-O-Phosphonylmethylribonucleosides II, III were prepared by intramolecular cyclisation of ribonucleoside 2'(3')-chloromethanephosphonates I in alkali.Treatment of the phosphonylmethyl derivatives with dicyclohexylcarbodiimide afforded cyclic six-membered esters VI, VII which are stable in acid and easily hydrolyze in alkali.Ribonucleases A, T1, T2, U2 and spleen cPDase do not split the cyclic phosphonate ester linkage of these analogues of ribonucleoside 2',3'-cyclic phosphates.