1008119-70-7Relevant articles and documents
Improving the pharmacokinetic and CYP inhibition profiles of azaxanthene-based glucocorticoid receptor modulators-identification of (S)-5-(2-(9-fluoro-2-(4-(2-hydroxypropan-2-yl)phenyl)-5 H -chromeno[2,3- b ]pyridin-5-yl)-2-methylpropanamido)-N-(tetrahydr
Yang, Michael G.,Dhar, T. G. Murali,Xiao, Zili,Xiao, Hai-Yun,Duan, James J.-W.,Jiang, Bin,Galella, Michael A.,Cunningham, Mark,Wang, Jinhong,Habte, Sium,Shuster, David,McIntyre, Kim W.,Carman, Julie,Holloway, Deborah A.,Somerville, John E.,Nadler, Steven G.,Salter-Cid, Luisa,Barrish, Joel C.,Weinstein, David S.
, p. 4278 - 4290 (2015/06/08)
An empirical approach to improve the microsomal stability and CYP inhibition profile of lead compounds 1a and 1b led to the identification of 5 (BMS-341) as a dissociated glucocorticoid receptor modulator. Compound 5 showed significant improvements in pha
FUSED HETEROARYL MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-KB ACTIVITY AND USE THEREOF
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Page/Page column 103, (2009/10/09)
Novel non-steroidal compounds are provided which are useful in treating diseases or disorders associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity, including metabolic and inflammatory and immune diseases or disorders, ha