3-Fluoro-4-(4-Morpholinylcarbonyl)benzeneboronic acid, 97%

Base Information

• Chemical Name: 3-Fluoro-4-(4-Morpholinylcarbonyl)benzeneboronic acid, 97%
• CAS No.: 1008119-70-7
• Molecular Formula: C11H13BFNO4
• Molecular Weight: 253.038
• Hs Code.: 2934999090
• Mol file: 1008119-70-7.mol

Synonyms:3-Fluoro-4-(4-Morpholinylcarbonyl)benzeneboronic acid, 97%;3-fluoro-4-(Morpholine-4-carbonyl)phenylboronic acid

Chemical Property of 3-Fluoro-4-(4-Morpholinylcarbonyl)benzeneboronic acid, 97%

Chemical Property:

• PSA: 70.00000
• LogP: -1.08420

Purity/Quality:

97% ^*data from raw suppliers

3-Fluoro-4-[(morpholin-4-yl)carbonyl]phenylboronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Fluoro-4-(4-Morpholinylcarbonyl)benzeneboronic acid, 97%

There total 1 articles about 3-Fluoro-4-(4-Morpholinylcarbonyl)benzeneboronic acid, 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

morpholine (110-91-8,99108-56-2) + 4-(dihydroxyboranyl)-2-fluorobenzoic acid (120153-08-4) → (3-fluoro-4-(morpholine-4-carbonyl)phenyl)boronic acid (1008119-70-7)

Guidance literature:

With HATU; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield: 72.41%

(3-fluoro-4-(morpholine-4-carbonyl)phenyl)boronic acid (1008119-70-7) + 5-bromo-3-(1-isopropyl-1H-[1,2,3]triazol-4-yl)-pyridin-2-ylamine (1617499-16-7) → (5-(6-amino-5-(1-isopropyl-1H-1,2,3-triazol-4-yl)pyridin-3-yl)-2-fluorophenyl)(morpholino)methanone (1617499-20-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; water; at 110 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

Reference yield: 46.0%

(S)-2-(2-chloro-5H-chromeno [2,3-b]pyridine-5-yl)-2-methylpropanoic acid + (3-fluoro-4-(morpholine-4-carbonyl)phenyl)boronic acid (1008119-70-7) → (S)-2-(2-(3-fluoro-4-(morpholine-4-carbonyl)phenyl)-5H-chromeno[2,3-b]pyridin-5-yl)-2-methylpropanoic acid

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 100 ℃; for 16h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.jmedchem.5b00257

upstream raw materials:

morpholine

4-(dihydroxyboranyl)-2-fluorobenzoic acid

Downstream raw materials:

(5-(6-amino-5-(1-isopropyl-1H-1,2,3-triazol-4-yl)pyridin-3-yl)-2-fluorophenyl)(morpholino)methanone

(4-(6-amino-5-(1-isopropyl-1H-1,2,3-triazol-4-yl)pyridin-3-yl)-2-fluorophenyl)(morpholino)methanone

5-[4-fluoro-3-(morpholinomethyl)phenyl]-3-(1-isopropyltriazol-4-yl)pyridin-2-amine