1008303-75-0Relevant academic research and scientific papers
Indole Synthesis via Cobalt(III)-Catalyzed Oxidative Coupling of N-Arylureas and Internal Alkynes
Zhang, Zhuo-Zhuo,Liu, Bin,Xu, Jing-Wen,Yan, Sheng-Yi,Shi, Bing-Feng
, p. 1776 - 1779 (2016)
A mild Co(III)-catalyzed oxidative annulation of N-arylureas and internal alkynes has been developed. The use of less electrophilic ureas other than acetamides as directing groups is crucial for the reaction. A broad range of synthetically useful functional groups are compatible with this reaction, thus providing a new opportunity for the synthesis of diverse indoles.
One-pot multicomponent synthesis of indoles from 2-iodobenzoic acid
Leogane, Olivier,Lebel, Helene
, p. 350 - 352 (2008/09/19)
(Chemical Equation Presented) A synergism: The multicomponent assembly of an alkyne, a nucleophile, and a carboxylic acid gave indole derivatives in good yield and high regioselectivity by a one-pot Curtius rearrangement/palladium- catalyzed indolization process (see scheme). A synergistic effect was observed; the by-product of the first reaction served as a reagent for the second step. The first synthesis of indole N-carboxamide derivatives by heteroannulation is also described.
