100833-41-8Relevant academic research and scientific papers
Design and synthesis of conformationally constrained 3-(N-alkylamino) propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors
Yan, Lin,Hale, Jeffrey J.,Lynch, Christopher L.,Budhu, Richard,Gentry, Amy,Mills, Sander G.,Hajdu, Richard,Keohane, Carol Ann,Rosenbach, Mark J.,Milligan, James A.,Shei, Gan-Ju,Chrebet, Gary,Bergstrom, James,Card, Deborah,Rosen, Hugh,Mandala, Suzanne M.
, p. 4861 - 4866 (2007/10/03)
A series of conformationally constrained analogs of 3 were synthesized and evaluated as S1P receptor agonists. Several novel scaffolds were identified as suitable for further investigation. A series of conformationally constrained 3-(N-alkylamino)propylphosphonic acids were systematically synthesized and their activities as S1P receptor agonists were evaluated. Several pyrrolidine and cyclohexane analogs had S1P receptor profiles comparable to the acyclic lead compound, 3-(N-tetradecylamino)propylphosphonic acid (3), lowered circulating lymphocytes in mice after iv administration and were thus identified as being suitable for further investigations.
Substituted pyridazines
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, (2008/06/13)
A liquid crystal compound containing an optically active group, suitable for being used for display mode utilizing ferroelectric liquid crystals, and a composition containing the same are provided, which compound is an optically active pyridazine compound
