1008361-76-9

Upstream product

• 76-83-5 trityl chloride 
• 87-42-3 6-chloropurine 
• 87-42-3 6-chloro-7H-purine 

Downstream Products

• 1258274-80-4 7-allyl-6-chloro-7,8-dihydro-9-tritylpurine 
• 1258274-81-5 6-chloro-7,8-dihydro-7-(3-methylbut-2-enyl)-9-tritylpurine 
• 1258274-85-9 6-chloro-7,8-dihydro-7-propargyl-9-tritylpurine 
• 1258274-87-1 6-chloro-7,8-dihydro-7-methyl-9-tritylpurine 
• 5440-17-5 6-chloro-7-methyl-7H-purine 
• 1928-77-4 7-benzyl-6-chloro-7H-purine 

Relevant academic research and scientific papers

NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS FOR OPIOID RECEPTORS

This invention relates to novel compounds which are antagonists or inverse agonists at one or more of the opioid receptors, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy.

Selective synthesis of 7-substituted purines via 7,8-dihydropurines

A simple and efficient protocol for the preparation of 7-substituted purines is described. 6- and 2,6-Dihalopurines were N9-tritylated and then transformed to 7,8-dihydropurines by DIBAL-H. Subsequent N 7-alkylation followed by N9-trityl deprotection with trifluoroacetic acid was accompanied by spontaneous reoxidation, which led to the 7-substituted purines at 55 - 88% overall isolated yields.