100844-12-0Relevant academic research and scientific papers
Development of tubulin-polymerization inhibitors based on the thalidomide skeleton
Aoyama, Hiroshi,Noguchi, Tomomi,Misawa, Takashi,Nakamura, Takanori,Miyachi, Hiroyuki,Hashimoto, Yuichi,Kobayashi, Hisayoshi
, p. 944 - 949 (2008/02/09)
We synthesized a series of compounds based on the potent tubulin-polymerization inhibitor 5-hydroxy-2-(2,6-diisopropylphenyl)-1H- isoindole-1,3-dione [5HPP-33 (3)], which is structurally derived from thalidomide (1), and investigated their inhibitory effe
Inhibitors of NF-κB derived from thalidomide
Carcache de-Blanco, Esperanza J.,Pandit, Bulbul,Hu, Zhigen,Shi, Jiandong,Lewis, Andrew,Li, Pui-Kai
, p. 6031 - 6035 (2008/09/17)
A series of compounds originally derived from thalidomide were synthesized and evaluated. The most potent compounds in this series, 5HPP-33 and compound 20, inhibited NF-κB activation in HeLa cells. Preliminary study indicated that the mechanism of inhibition of NF-κB activation is through inhibition of its translocation from the cytoplasm to the nucleus.
