1008509-04-3Relevant articles and documents
Pivotal role of an aliphatic side chain in the development of an HDM2 inhibitor
Ma, Yao,Lahue, Brian R.,Gibeau, Craig R.,Shipps, Gerald W.,Bogen, Stéphane L.,Wang, Yaolin,Guo, Zhuyan,Guzi, Timothy J.
, p. 572 - 575 (2014)
Introduction of an aliphatic side chain to a key position of a novel piperidine-based HDM2 inhibitor scaffold resulted in significant potency gains, enabling further series progression.
Substituted Piperidines that Increase P53 Activity and the Uses Thereof
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Page/Page column 65, (2008/06/13)
In its many embodiments, the present invention discloses novel compounds, as inhibitors of HDM2 protein, methods for preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of treatment, prevention, inhibition, of one or more diseases associated with the HDM2 protein or P53 using such compounds or pharmaceutical compositions.
