1008517-95-0Relevant articles and documents
Design, synthesis and evaluation of MCH receptor 1 antagonists - Part III: Discovery of pre-clinical development candidate BI 186908
Oost, Thorsten,Heckel, Armin,Kley, J?rg T.,Lehmann, Thorsten,Müller, Stephan,Roth, Gerald J.,Rudolf, Klaus,Arndt, Kirsten,Budzinski, Ralph,Lenter, Martin,Lotz, Ralf R.H.,Maier, Gerd-Michael,Markert, Michael,Thomas, Leo,Stenkamp, Dirk
, p. 3275 - 3280 (2015)
Abstract Although overweight and obesity are highly prevalent conditions, options to treat them are still very limited. As part of our search for safe and effective MCH-R1 antagonists for the treatment of obesity, two series of pyridones and pyridazinones
Nitrooxymethyl-substituted analogues of Rofecoxib: Synthesis and pharmacological characterization
Boschi, Donatella,Cena, Clara,Di Stilo, Antonella,Rolando, Barbara,Manzini, Paola,Fruttero, Roberta,Gasco, Alberto
experimental part, p. 1173 - 1182 (2011/08/07)
Nitrooxymethyl-substituted derivatives of Rofecoxib were synthesized and tested for their cyclooxygenase (COX)-inhibiting activity in whole human blood, vasodilator potency on rat aorta strips, and for their capacity of inhibiting platelet aggregation of
PYRIDONE AND PYRIDAZINONE DERIVATIVES AS MCH ANTAGONISTS
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Page/Page column 36, (2009/10/18)
The present invention relates to pyridone and pyridazinone derivatives as listed in claim 1 including their salts. Moreover the invention relates to pharmaceutical compositions containing at least one compound according to the invention. By virtue of thei
NEW PYRIDONE DERIVATIVES WITH MCH ANTAGONISTIC ACTIVITY AND MEDICAMENTS COMPRISING THESE COMPOUNDS
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Page/Page column 89-90, (2008/06/13)
The present invention relates to compounds of general formula (I) wherein the groups and radicals B, k, L, U,V, W, X, Y, Z, R1, R2, have the meanings given in claim 1. Moreover the invention relates to pharmaceutical compositions containing at least one compound according to the invention. By virtue of their MCH- receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.