75633-63-5

Basic information

• Product Name: Ethanone, 1-[4-(hydroxymethyl)phenyl]- (9CI)
• Synonyms: Ethanone, 1-[4-(hydroxymethyl)phenyl]- (9CI);1-(4-Hydroxymethylphenyl)ethanone;4-(Hydroxymethyl)acetophenone;4-Acetylbenzyl alcohol;4'-Hydroxymethylacetophenone;p-Acetylbenzyl alcohol;4-(Hydroxymethy)acetophenone;Ethanone, 1-[4-(hydroxymethyl)phenyl]-
• CAS NO: 75633-63-5
• Molecular Formula: C₉H₁₀O₂
• Molecular Weight: 150.1745
• Product Categories: ACETYLGROUP
• Mol File: 75633-63-5.mol
• Article Data: 105

Chemical Properties

• Melting Point: 54 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 301℃
• Flash Point: 127℃
• Appearance: /
• Density: 1.114
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.94±0.10(Predicted)
• CAS DataBase Reference: Ethanone, 1-[4-(hydroxymethyl)phenyl]- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[4-(hydroxymethyl)phenyl]- (9CI)(75633-63-5)
• EPA Substance Registry System: Ethanone, 1-[4-(hydroxymethyl)phenyl]- (9CI)(75633-63-5)

Safety Data

• Hazardous Substances Data: 75633-63-5(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-[4-(hydroxymethyl)phenyl]- (9CI), also known as 4-(Hydroxymethyl)acetophenone, is a chemical compound with the formula C9H10O2. This organic compound belongs to the class of phenols, which are compounds containing a phenol group -OH connected directly to an aromatic hydrocarbon group. It exhibits properties of both ketone and alcohol, as it contains a carbonyl group (C=O) and a hydroxyl group (-OH). Commonly used in the field of organic synthesis, this compound is noted for its colorless or light yellow appearance and sweetish taste and is widely used as an intermediate in the manufacturing of dyes, pharmaceuticals, and pesticides.

Upstream product

• 408334-85-0 4-(1,1-diethoxy-ethyl)-benzoic acid ethyl ester 
• 80463-22-5 4-(1-hydroxyethyl)benzyl alcohol 
• 408334-58-7 1-(4-hydroxymethyl-phenyl)-ethanone-diethylacetal 
• 3609-53-8 methyl 4-acetylbenzoate 
• 3457-45-2 p-formylacetophenone 
• 59016-93-2 p-hydroxymethylphenylboronic acid 
• 586-89-0 4-acetyl-benzoic acid 
• 95827-11-5 4’-(acetoxymethyl)acetophenone 
• 108-88-3 toluene 
• 123-08-0 4-hydroxy-benzaldehyde 
• 17763-69-8 4-(trifluormethanesulfonyloxy)benzaldehyde 
• 91-63-4 2-methylquinoline 
• 10602-04-7 (4-ethynylphenyl)methanol 
• 873-75-6 4-bromobenzenemethanol 

Downstream Products

• 1312214-65-5 (-)-1-(4-hydroxymethylphenyl)ethanol 
• 80463-22-5 4-(1-hydroxyethyl)benzyl alcohol 
• 768-59-2 4-ethylbenzyl alcohol 
• 1184945-53-6 4-benzyloxy-1-{2-[4-(4-methoxy-4-methyl-piperidin-1-ylmethyl)-phenyl]-2-oxo-ethyl}-1H-pyridin-2-one 
• 1184949-08-3 4-benzyloxy-1-[2-(4-imidazol-1-ylmethyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-one 
• 912819-58-0 4-[4-(4-cyano-benzoyl)-1,9b-dihydro-5-oxa-3,3a-diaza-cyclopenta[a]naphthalen-2-yl]-benzyl alcohol 
• 912819-59-1 4-[4-(4-cyano-benzoyl)-1,9b-dihydro-5-oxa-3,3a-diaza-cyclopenta[a]naphthalen-2-yl]-benzaldehyde 
• 912819-56-8 4-[3-(2-hydroxy-phenyl)-acryloyl]-benzyl alcohol 

Relevant articles and documents

APPLICATION OF THE COMBINATION OF SODIUM BISULFITE AS A PROTECTIVE REAGENT AND SOLID SUPPORTS IN THE SELECTIVE REDUCTION OF 4-ACETYLBENZALDEHYDE WITH DIBORANE

4-Acetylbenzaldehyde (2) has been selectively reduced by using a combination of protective group and solid supports.The formyl group of 2 was protected by addition of sodium bisulfite.The adduct, supported on silica gel, was then selectively reduced to 4-

Visible Light Induced Reduction and Pinacol Coupling of Aldehydes and Ketones Catalyzed by Core/Shell Quantum Dots

We present an efficient and versatile visible light-driven methodology to transform aryl aldehydes and ketones chemoselectively either to alcohols or to pinacol products with CdSe/CdS core/shell quantum dots as photocatalysts. Thiophenols were used as proton and hydrogen atom donors and as hole traps for the excited quantum dots (QDs) in these reactions. The two products can be switched from one to the other simply by changing the amount of thiophenol in the reaction system. The core/shell QD catalysts are highly efficient with a turn over number (TON) larger than 4 × 104 and 4 × 105 for the reduction to alcohol and pinacol formation, respectively, and are very stable so that they can be recycled for at least 10 times in the reactions without significant loss of catalytic activity. The additional advantages of this method include good functional group tolerance, mild reaction conditions, the allowance of selectively reducing aldehydes in the presence of ketones, and easiness for large scale reactions. Reaction mechanisms were studied by quenching experiments and a radical capture experiment, and the reasons for the switchover of the reaction pathways upon the change of reaction conditions are provided.

KB3H8: An environment-friendly reagent for the selective reduction of aldehydes and ketones to alcohols

Selective reduction of aldehydes and ketones to their corresponding alcohols with KB3H8, an air- and moisture-stable, nontoxic, and easy-to-handle reagent, in water and THF has been explored under an air atmosphere for the first time. Control experiments illustrated the good selectivity of KB3H8 over NaBH4 for the reduction of 4-acetylbenzaldehyde and aromatic keto esters. This journal is