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1008529-50-7

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1008529-50-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1008529-50-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,8,5,2 and 9 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1008529-50:
(9*1)+(8*0)+(7*0)+(6*8)+(5*5)+(4*2)+(3*9)+(2*5)+(1*0)=127
127 % 10 = 7
So 1008529-50-7 is a valid CAS Registry Number.

1008529-50-7Relevant articles and documents

Discovery of TRPV1 antagonist ABT-116

Brown, Brian S.,Keddy, Ryan,Perner, Richard J.,DiDomenico, Stanley,Koenig, John R.,Jinkerson, Tammie K.,Hannick, Steven M.,McDonald, Heath A.,Bianchi, Bruce R.,Honore, Prisca,Puttfarcken, Pamela S.,Moreland, Robert B.,Marsh, Kennan C.,Faltynek, Connie R.,Lee, Chih-Hung

scheme or table, p. 3291 - 3294 (2010/08/07)

The synthesis and SAR of a series of indazole TRPV1 antagonists leading to the discovery of 21 (ABT-116) is described. Biological studies demonstrated potent in vitro and in vivo activity for 21, as well as suitable physicochemical and pharmacokinetic pro

METHODS FOR MAKING CENTRAL NERVOUS SYSTEM AGENTS THAT ARE TRPV1 ANTAGONISTS

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Page/Page column 41-42, (2009/10/22)

The invention discloses compounds of formula ( II ): and methods of making the compounds, which are VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.

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