100858-33-1

Basic information

• Product Name: (R)-1-CBZ-3-PYRROLIDINOL
• Synonyms: (R)-(-)-1-CBZ-3-HYDROXY-PYRROLIDINE ;(R)-benzyl 3-hydroxypyrrolidine-1-carboxylate;(R)-N-Cbz-3-hydroxypyrrolidine;(R)-3-Hydroxy-pyrrolidine-1-carboxylic acid benzyl ester;N-Cbz-3(R)-hydroxypyrrolidine;(R)-1-Benzyloxycarbonyl-3-pyrrolidinol, (R)-1-Carbobenzoxy-3-pyrrolidinol, (R)-N-Z-3-Pyrrolidinol;(R)-(-)-1-Cbz-3-pyrrolidinol;(R)-1-Cbzl-3-pyrrolidinol
• CAS NO: 100858-33-1
• Molecular Formula: C₁₂H₁₅NO₃
• Molecular Weight: 221.2524
• Mol File: 100858-33-1.mol
• Article Data: 28

Chemical Properties

• Melting Point: 74-79 °C
• Boiling Point: 370.7 °C at 760 mmHg
• Flash Point: 178 °C
• Appearance: /
• Density: 1.263 g/cm³
• Vapor Pressure: 3.75E-06mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: soluble in Chloroform
• PKA: 14.72±0.20(Predicted)
• CAS DataBase Reference: (R)-1-CBZ-3-PYRROLIDINOL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-CBZ-3-PYRROLIDINOL(100858-33-1)
• EPA Substance Registry System: (R)-1-CBZ-3-PYRROLIDINOL(100858-33-1)

Safety Data

• Hazard Codes: T
• Statements: 25-36/37/38
• Safety Statements: 26-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 100858-33-1(Hazardous Substances Data)

Usage

Chemical Properties

White to brown crystal to powder

InChI:InChI=1/C12H15NO3/c14-11-6-7-13(8-11)12(15)16-9-10-4-2-1-3-5-10/h1-5,11,14H,6-9H2/t11-/m1/s1

Upstream product

• 31970-04-4 1-carboxybenzyl-3-pyrrolidine 
• 104706-47-0 (R)-3-hydroxypyrrolidine hydrochloride 
• 501-53-1 benzyl chloroformate 
• 40499-83-0 (3R)-pyrrolidinol 
• 174621-88-6 (S)-3-(acetyloxy)-1-pyrrolidinecarboxylic acid, phenylmethyl ester 
• 25070-74-0 1-benzyloxycarbonylpyrrolidine 
• 95656-88-5 benzyl 3-hydroxypyrrolidine-1-carboxylate 
• 122536-94-1 (S)-3-hydroxypyrrolidine hydrochloride 
• 108-22-5 Isopropenyl acetate 
• 130312-02-6 benzyl 3-oxopyrrolidine-1-carboxylate 

Downstream Products

• 130403-93-9 (S)-benzyl 3-acetoxypyrrolidine-1-carboxylate 
• 1316848-03-9 (S)-benzyl 3-(((S)-1-(tert-butoxy)-1-oxopropan-2-yl)amino)pyrrolidine-1-carboxylate 
• 1316847-95-6 (S)-benzyl 3-(((S)-1-(tert-butoxy)-1-oxo-3-phenylpropan-2-yl)amino)pyrrolidine-1-carboxylate 
• 1316848-05-1 C₂₂H₃₄N₂O₄ 
• 1316847-99-0 (S)-benzyl 3-(((S)-1-(tert-butoxy)-1-oxo-3-phenylpropan-2-yl)amino)pyrrolidine-1-carboxylate hydrochloride 
• 1316848-04-0 C₁₉H₂₈N₂O₄*ClH 

Relevant articles and documents

Stereo-complementary bioreduction of saturated N-heterocyclic ketones

The asymmetric bioreduction of several saturated N-heterocyclic ketones is demonstrated in a stereo-complementary fashion using the ketoreductases READH and ChKRED20 for the production of (S)- and (R)-alcohols, respectively. The reaction accepts substrates with a five-, six- or seven-membered ring, and exhibits excellent stereoselectivity when using 2-propanol as both the ultimate reducing agent and cosolvent, achieve >99% ee in the majority of cases for both enantiomers.

NOVEL HETEROCYCLIC COMPOUNDS AS TYROSINE KINASE BCR-ABL INHIBITORS

Disclosed is a compound of Formula (Ⅰ) or a pharmaceutically acceptable salt thereof, wherein the variables are described herein. Also disclosed is a process for the preparation of compounds, their pharmaceutical compositions comprising the same as an active ingredient, methods using said compositions in the treatment of various disorders, and use of the compounds in the manufacture of a medicament in inhibition of the enzymatic activities of ABL1, ABL2 and related chimeric proteins.

Pyrrolinone-pyrrolidine oligomers as universal peptidomimetics

Peptidomimetics 1-3 were prepared from amino acid-derived tetramic acids 7 as the key starting materials. Calculations show that preferred conformations of 1 can align their side-chain vectors with amino acids in common secondary structures more effectively than conformations of 3. A good fit was found for a preferred conformation of 2 (an extended derivative of 1) with a sheet/β-turn/sheet motif.