100866-24-8

Basic information

• Product Name: 3-phenyl-3-(2-pyridyl)propanal
• Synonyms: 3-phenyl-3-(2-pyridyl)propanal
• CAS NO: 100866-24-8
• Molecular Weight: 211.263
• Mol File: 100866-24-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-phenyl-3-(2-pyridyl)propanal(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenyl-3-(2-pyridyl)propanal(100866-24-8)
• EPA Substance Registry System: 3-phenyl-3-(2-pyridyl)propanal(100866-24-8)

Safety Data

• Hazardous Substances Data: 100866-24-8(Hazardous Substances Data)

Upstream product

• 15260-65-8 2-(1-phenylvinyl)pyridine 
• 201230-82-2 carbon monoxide 
• 233760-11-7 2-(2-[1,3]dioxolan-2-yl-1-phenyl-ethyl)-pyridine 
• 101-82-6 2-Benzylpyridine 
• 140-29-4 phenylacetonitrile 
• 121504-36-7 3-phenyl-4,4-diethoxybutanenitrile 
• 109-04-6 2-bromo-pyridine 
• 233760-13-9 N,N-dimethyl-4-phenyl-4-(2-pyridyl)-2-hydroxybutanamide 

Downstream Products

• 86-21-5 pheniramine 

Relevant articles and documents

New synthetic route to N,N-disubstituted 3-aryl-3-pyridylpropylamines: Pheniramines from 3-aryl-3-(2-pyridyl)propanals

3-Aryl-3-(2-pyridyl)propanals 3, useful precursors compound for the H1 antihistaminic agents Pheniramines 1 were prepared following three different reaction pathways: the first one involves the rhodium catalyzed regiospecific hydroformylation of cinnamaldehyde acetals 4; the second one was carried out through the hydro-hydroxyacetamidation reaction on 1-aryl-1-(2-pyridyl)ethenes 2 followed by oxidative cleavage of the intermediate α-hydroxybutanamides 10; the third one was accomplished through alkylation of 2-benzylpyridines 12 with 2-bromomethyl-1,3-dioxolane 13 using LDA as deprotonating agent. The last preparative route showed to be the most convenient giving Pheniramine 1 up to 80 percent overall yield.