100866-58-8Relevant academic research and scientific papers
An efficient method for the synthesis of 2-pyridones: Via C-H bond functionalization
Zhou, Shuguang,Liu, Duan-Yang,Wang, Suo,Tian, Jie-Sheng,Loh, Teck-Peng
, p. 15020 - 15023 (2020/12/23)
A simple and practical method to access N-substituted 2-pyridones via a formal [3+3] annulation of enaminones with acrylates based on RhIII-catalyzed C-H functionalization was developed. Control and deuterated experiments led to a plausible mechanism involving C-H bond cross-coupling and aminolysis cyclization. This strategy provides a short synthesis of structural motifs of N-substituted 2-pyridones.
