100875-61-4

Basic information

• Product Name: 2-(4-aminophenoxy)-N-cyclohexylacetamide
• Synonyms: 2-(4-aminophenoxy)-N-cyclohexylacetamide
• CAS NO: 100875-61-4
• Molecular Weight: 248.325
• Mol File: 100875-61-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(4-aminophenoxy)-N-cyclohexylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-aminophenoxy)-N-cyclohexylacetamide(100875-61-4)
• EPA Substance Registry System: 2-(4-aminophenoxy)-N-cyclohexylacetamide(100875-61-4)

Safety Data

• Hazardous Substances Data: 100875-61-4(Hazardous Substances Data)

Upstream product

• 108-91-8 cyclohexylamine 
• 20142-88-5 2-(4-nitrophenoxy)acetyl chloride 
• 23605-23-4 2-Chloro-N-cyclohexylacetamide 
• 110506-25-7 N-cyclohexyl-2-(4-nitrophenoxy)acetamide 

Downstream Products

• 110506-72-4 N-Cyclohexyl-2-(4-isothiocyanato-phenoxy)-acetamide 
• 936632-81-4 1-deoxy-1-(6-{4-[(cyclohexylcarbamoyl)methoxy]phenylamino}-9H-purin-9-yl)-N-ethyl-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide 
• 936632-85-8 1-deoxy-1-(2-chloro-6-{4-[(cyclohexylcarbamoyl)methoxy]phenylamino}-9H-purin-9-yl)-N-ethyl-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide 

Relevant articles and documents

N6-[(Hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5′-N-ethylcarboxamido-adenosines: The first example of adenosine-related structures with potent agonist activity at the human A2B adenosine receptor

A new series of N6-[(hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5′-N-ethylcarboxamido-adenosines (24-43) has been synthesised and tested in binding assays at hA1, hA2A and hA3 adenosine receptors, and in a functional assay at the hA2B subtype. The examined compounds displayed high potency in activating A2B receptors with good selectivity versus A2A subtypes. The introduction of an unsubstituted 4-[(phenylcarbamoyl)-methoxy]-phenyl chain at the N6 position of 5′-N-ethylcarboxamido-adenosine led us to the recognition of compound 24 as a full agonist displaying the highest efficacy of the series (EC50 hA2B = 7.3 nM). These compounds represent the first report about adenosine-related structures capable of activating hA2B subtype in the low nanomolar range.