100883-38-3Relevant academic research and scientific papers
Synthesis of 2-substituted 1,3-cycloheptanedione via a lewis acid mediated ring expansion reaction
Inomata, Kohei,Endo, Yasuyuki
, p. 997 - 1012 (2014/01/17)
We have established a new route to provide 2-substituted 1,3-cycloheptanediones via a Lewis acid mediated ring expansion reaction of cyclobutanones as the key step. The ring expansion reactions were mediated by a series of Lewis acids. Among the used Lewis acids, ZnI2 was the most practical mediator. This route has succeeded in providing the title compounds even on a multi-gram scale. During the research, the Baeyer-Villiger oxidation of the cyclobutanones to obtain the new bicyclic lactones was also examined. The regioselective oxidation was observed in the case of chlorinated cyclobutanones.
Problems in Selective Catalysis with Molecular Imprints in Silica - Selective Lactones Formation from Hydroxyesters in Micropores
Heilmann, Jens,Maier, Wilhelm F.
, p. 460 - 468 (2007/10/02)
Selective lactone formation from hydroxy esters can be obtained with microporous glass catalysts.By a sol-gel polycocondensation of TEOS and a cyclic phosphonate an imprinted microporous silica catalyst was prepared.The imprint molecule selected is a transition state analogue for the lactone formation from hydroxy esters.Although selective γ- and δ-lactone formation from the respective hydroxy esters was observed, control experiments revealed, that the catalytic selectivity of the lactone formation is already obtained by the micropores of the material and not associated to the imprint.The study illustrates the importance of proper control experiments for the evaluation of imprint effects in selectively catalyzed reactions. - Keywords: Micropores, Selective Lactones Formation, Silica Catalyst
