100886-20-2

Upstream product

• 2859-78-1 4-Bromoveratrole 
• 100-67-4 potassium phenolate 
• 139-02-6 sodium phenoxide 
• 5460-32-2 1-iodo-3,4-dimethoxybenzene 
• 91-16-7 1,2-dimethoxybenzene 
• 2033-89-8 3,4-dimethoxyphenol 
• 591-50-4 iodobenzene 
• 108-95-2 phenol 

Downstream Products

• 42833-49-8 2,3-dimethoxy-9H-xanthen-9-one 
• 857000-45-4 1-chloromethyl-4,5-dimethoxy-2-phenoxy-benzene 
• 1138-67-6 3,4-Dihydroxydiphenyl ether 
• 23396-64-7 2-(3,4-dimethoxyphenoxy)benzaldehyde 
• 101790-80-1 (4,5-dimethoxy-2,4'-oxy-diphenyl)-di-acetic acid 
• 875816-78-7 1-(4,5-dimethoxy-2-phenoxy-phenyl)-ethanone 
• 95546-50-2 3,4-dimethoxybenzenesulfonyl fluoride 
• 855937-81-4 (4,5-dimethoxy-2-phenoxy-phenyl)-acetonitrile 
• 855589-96-7 4,5-dimethoxy-2-phenoxy-phenethylamine 
• 717909-76-7 2-bromo-1-(4,5-dimethoxy-2-phenoxy-phenyl)-ethanone 
• 857724-14-2 1-(4,5-dimethoxy-2-phenoxy-phenyl)-2-piperidino-ethanone 
• 104780-51-0 (4,5-dimethoxy-2,4'-oxy-diphenyl)-di-acetic acid bis-(4-benzyloxy-3-methoxy-phenethylamide) 

Relevant academic research and scientific papers

Transition-Metal-Free C3 Arylation of Indoles with Aryl Halides

We report an unprecedented transition metal-free coupling of indoles with aryl halides. The reaction is promoted by KOtBu and is regioselective for C3 over N. The use of degassed solvents devoid of oxygen is necessary for the success of the transformation. Preliminary studies implicate a hybrid mechanism that involves both aryne intermediates and non-propagative radical processes. Electron transfer is also a distinct possibility. These conclusions were substantiated by EPR data, isotopic labeling studies, and the use of radical scavengers and electron transfer inhibitors.

Biotransformation of diphenyl ether by the yeast Trichosporon beigelii SBUG 752

Trichosporon beigelii SBUG 752 was able to transform diphenyl ether. By TLC, HPLC, GC, GC-MS, NMR- and UV-spectroscopy, several oxidation products were identified. The primary attack was initiated by a monooxygenation step, resulting in the formation of 4-hydroxydiphenyl ether, 2-hydroxydiphenyl ether and 3-hydroxydiphenyl ether (48:47:5). Further oxidation led to 3,4-dihydroxydiphenyl ether. As a characteristic product resulting from the cleavage of an aromatic ring, the lactone of 2-hydroxy-4-phenoxymuconic acid was identified. The possible mechanism of ring cleavage to yield this metabolite is discussed.