1009-70-7

Basic information

• Product Name: 2-(Phenylamino)-4,5-dihydrothiazole
• Synonyms: 2-(Phenylamino)-4,5-dihydrothiazole;2-(Phenylimino)thiazolidine;2-Anilino-2-thiazoline;N-(Thiazolidine-2-ylidene)aniline;N-Phenyl-2-thiazoline-2-amine;N-Phenylthiazolidine-2-imine;2-Thiazoline, 2-anilino-;N-phenyl-4,5-dihydrothiazol-2-amine
• CAS NO: 1009-70-7
• Molecular Formula: C₉H₁₀N₂S
• Molecular Weight: 178.26
• Mol File: 1009-70-7.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 300.5°Cat760mmHg
• Flash Point: 135.6°C
• Appearance: /
• Density: 1.23g/cm³
• Vapor Pressure: 0.00111mmHg at 25°C
• Refractive Index: 1.653
• CAS DataBase Reference: 2-(Phenylamino)-4,5-dihydrothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Phenylamino)-4,5-dihydrothiazole(1009-70-7)
• EPA Substance Registry System: 2-(Phenylamino)-4,5-dihydrothiazole(1009-70-7)

Safety Data

• Hazardous Substances Data: 1009-70-7(Hazardous Substances Data)

Usage

General Description

2-(Phenylamino)-4,5-dihydrothiazole is a chemical compound with the molecular formula C9H10N2S. It is a heterocyclic compound that contains a thiazole ring with a phenylamino group attached to it. 2-(Phenylamino)-4,5-dihydrothiazole is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and pharmaceuticals. It has also shown potential as an antimicrobial and antifungal agent. Additionally, 2-(Phenylamino)-4,5-dihydrothiazole has been studied for its potential use in the development of new materials and for its biological and pharmacological properties. Overall, this chemical compound has a wide range of applications and is of interest to researchers in various fields.

InChI:InChI=1/C9H10N2S/c1-2-4-8(5-3-1)11-9-10-6-7-12-9/h1-5H,6-7H2,(H,10,11)

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 91-22-5 quinoline 
• 541-41-3 chloroformic acid ethyl ester 
• 2058-74-4 1-methyl-1H-indole-2,3-dione 
• 14371-10-9 (E)-3-phenylpropenal 
• 19116-37-1 N-Phenyl-N'-ethylen-thioharnstoff 
• 67528-51-2 5-hydro-1,6-dioxa-4,9-diaza-5-phosphaspiro[4.4]nonane 
• 64-17-5 ethanol 
• 102-12-5 N-2-hydroxyethyl-N'-phenylthiourea 
• 62-53-3 aniline 
• 4921-82-8 1-benzoyl-3-phenylthiourea 
• 2576-47-8 2-bromoethylamine hydrobromide 
• 103-85-5 monophenylthiourea 
• 40836-94-0 2-methylsulfanyl-4,5-dihydrothiazoline hydroiodide 

Downstream Products

• 21224-34-0 2,3-dihydro-(4H)benzimidazo<2,1-b>thiazole 
• 5777-51-5 1-(4,5-dihydro-thiazol-2-yl)-1,3-bis-(4-fluoro-phenyl)-thiourea 
• 71998-64-6 N-phenyl-2-phenyliminotetrahydro-1,3-thiazole-2-carbothioamide 
• 2933-37-1 N-(4,5-dihydro-3-methyl-1,3-thiazol-2-ylidene)aniline 

Relevant articles and documents

Regioselective Synthesis of α- And γ-Amino Quinolinyl Phosphonamides Using N-Heterocyclic Phosphines (NHPs)

A regioselective phosphonylation of quinolines for the synthesis of α-amino quinolinyl phosphonamides and γ-amino quinolinyl phosphonamides has been developed under mild reaction conditions. An NHP-thiourea enables selective synthesis of α-amino quinolinyl phosphonamides by a Reissert-type reaction, and an NHP-tosylamide affords γ-amino quinolinyl phosphonamides via a 1,4-conjugate addition reaction. The corresponding amino quinolinyl phosphonate adducts were obtained in moderate to excellent yields (up to 99% yield) and regioselectivities (up to 99:1) with good functional group tolerance.

Amine-Catalyzed Phospha-Michael Reaction of α,β-Unsaturated Aldehydes and Ketones with Multifunctional N-Heterocyclic Phosphine-Thioureas as Phosphonylation Reagent

An efficient amine-catalyzed phospha-Michael addition reaction of α,β-unsaturated aldehydes/ketones with N-heterocyclic phosphines for the synthesis of ?-ketodiazaphosphonates has been developed. With freedom from nucleophile additives, this mild process affords a range of structurally diverse ?-ketodiazaphosphonates in moderate to excellent yields. Importantly, various α,β-unsaturated ketones were also tolerated in this process and gave moderate yields.

A Bench-Stable Vilsmeier Reagent for in situ Alcohol Activation: Synthetic Application in the Synthesis of 2-Amino-2-Thiazolines

A robust, chemoselective direct condensation/cyclization of thioureas and amino alcohols is described. Employing a bench-stable Vilsmeier reagent, methoxymethylene- N, N -dimethyliminium methyl sulfate, the selective in situ activation of alcohols is achieved with high efficiency and broad functional-group tolerance. The reversible interaction of the Vilsmeier reagent with substrate was key to the success of this activation strategy.