1009-80-9Relevant academic research and scientific papers
Diastereoselective synthesis of functionalized tetrahydropyrimidin-2- thiones via ZnCl2 promoted one-pot reactions
Liu, Zhenming,Zhang, Lili,Sun, Jing,Yan, Chaoguo
, p. 172 - 178 (2014)
In the presence of zinc chloride, the in situ generated β-enamino ester from the reaction of morpholine, piperidine and pyrrolidine with methyl propiolate reacted, with aromatic aldehydes and thiourea in ethanol resulting in the functionalized tetrahydrop
NNN-pincer-copper complex immobilized on magnetic nanoparticles as a powerful hybrid catalyst for aerobic oxidative coupling and cycloaddition reactions in water
Zohreh, Nasrin,Jahani, Mahboobeh
, p. 117 - 129 (2017)
A simple and reliable methodology is described for preparing the first heterogeneous NNN-pincer-copper hybrid catalyst with a high control over surface composition. The strategy relies on the covalently bonding of 2-aminopyridine to cyanuric chloride-functionalized magnetic nanoparticles followed by complexation with CuI. These claims are confirmed by different characterization methods such as SEM, TEM, FT-IR, TGA, ICP, XRD, and elemental analysis. The finely engineered supported catalyst is employed in the aerobic oxidative coupling of terminal alkynes and click reaction using only 0.38 and 0.04 mol% catalyst, respectively. All reactions perform under solvent-free condition or green solvent H2O. Also, the catalyst is readily recovered and reused for up to 8 and 6 subsequent runs in click and homocoupling reactions without significant loss of activity or leaching.
CINNOLINES AS INHIBITORS OF HPK 1
-
Page/Page column 49-50, (2021/01/29)
Compounds of Formula (I) or (Ia), pharmaceutically acceptable salts, stereoisomers, tautomers, solvates or prodrugs, and their use as HPK1 inhibitors are described herein, and also described are methods for preparing the compounds, and methods of treating HPK1-dependent diseases or disorders, such as cancer.
