15294-84-5

Upstream product

• 110-91-8 morpholine 
• 51608-61-8 N-(2,2,2-trichloroethyliden)-p-toluenesulfonamide 
• 941-55-9 4-toluenesulfonyl azide 
• 92050-44-7 methyl β-morpholinomethacrylate 
• 4394-85-8 4-morpholinecarboxaldehyde 
• 70-55-3 toluene-4-sulfonamide 
• 109-02-4 4-methyl-morpholine 
• 51759-38-7 4-{4-[2-(4-chloro-phenyl)-2H-tetrazol-5-yl]-buta-1,3-dienyl}-morpholine 
• 98-59-9 p-toluenesulfonyl chloride 
• 623-47-2 propynoic acid ethyl ester 
• 121-44-8 triethylamine 
• 1423-60-5 methyl ethynyl ketone 
• 1009-80-9 methyl 3-(morpholin-4-yl)acrylate 
• 68321-77-7 ethyl 3-(morpholin-4-yl)acrylate 

Downstream Products

• 1192-58-1 N-methylpyrrole aldehyde 

Relevant academic research and scientific papers

Copper-Catalyzed Coupling of Sulfonamides with Alkylamines: Synthesis of (E)-N-Sulfonylformamidines

Herein, we describe an efficient copper-catalyzed coupling of sulfonamides with alkylamines to synthesize (E)-N-sulfonylformamidines. The reaction is accomplished under mild conditions without the use of a corrosive acid or base as an additive. It tolerat

Three-component synthesis of N-sulfonylformamidines in the presence of magnetic cellulose supported N-heterocyclic carbene-copper complex, as an efficient heterogeneous nanocatalyst

A cellulose based magnetic nanocomposite possessing NHC-Cu Complex has been synthesized and characterized. It was then applied as a highly active catalyst in one-pot three-component reaction of sulfonyl azides, secondary amines and triethylamine to afford

Synthesis of Aryl- and Hetarylpyrazoles

Hetaryldieneamines (1) react with sulfonyl azides to give 3-hetarylpyrazoles (5).Similarly, N,N-dimethyl-4-phenyldieneamine-2-carboxylic acid methyl ester (6) affords 3-phenylpyrazole-5-carboxylic acid methyl ester (7). - Keywords: Cycloaddition; Dieneami

Rapid and efficient synthesis of formamidines in a catalyst-free and solvent-free system

An operationally rapid and efficient synthesis of N-sulfonyl formamidines that proceeds under mild conditions was achieved by reaction of a mixture of an amine, a sulfonyl azide, and a terminal ynone under catalyst-free and solvent-free conditions. Terminal ynones provide the C source to formamidines via complete cleavage of CC. This journal is

Catalyst-free one-pot, four-component approach for the synthesis of di- And tri-substituted: N -sulfonyl formamidines

A straightforward one-pot, multicomponent approach was developed to synthesize di- and tri-substituted N-sulfonyl formamidines from sulfonyl chlorides, NaN3, ethyl propiolate, and primary/secondary amines under mild conditions without catalysts or additives. Structural analysis of the di-substituted sulfonyl formamidines indicated formation of the E-syn/anti isomeric form. Tri-substituted analogues only formed E-isomers.

Preparation method of sulfonyl formamidine derivative

The invention relates to a preparation method of a sulfonyl formamidine derivative, which comprises the following step: reacting an amine compound with a terminal alkyne ketone compound and sulfonyl azide to obtain the sulfonyl formamidine derivative. The preparation method disclosed by the invention has the advantages of high product yield, high purity, high atom economy and the like, has good scientific research value and application prospect, provides a brand new route for preparation of the sulfonyl formamidine derivative, can play an important role in the fields of drug intermediates, pesticide intermediates and the like, reduces the production cost, and has good application value and potential in industry and scientific research.

Electrochemically generatedN-iodoaminium species as key intermediates for selective methyl sulphonylimination of tertiary amines

Reported herein is a straightforward protocol for approachingN-sulphonylamidinesviaan electricity-driven, iodine-mediated cross dehydrogenative condensation (CDC) between sulphonamides and tertiary amines, which features exclusive N-CH3selectivity for the amine partners. Mechanistic studies indicate that anin situgeneratedN-iodoaminium species serves as the key intermediate.

Visible-Light-Mediated Sulfonylimination of Tertiary Amines with Sulfonylazides Involving Csp3-Csp3 Bond Cleavage

Visible-light-induced cross-coupling of arylsulfonyl azides with tertiaryamines in the presence of Eosin Y at room temperature has been achieved. This transformation features alkyl C-C bond cleavage and provides a green approach to N-sulfonylamidines under mild conditions.

The C=C Bond Decomposition Initiated by Enamine-Azide Cycloaddition for Catalyst- and Additive-Free Synthesis of N-Sulfonyl Amidines

The chemo-selective synthesis of N-sulfonyl amidines is realized via the decomposition of the enamine C=C bond of enaminoesters through an in situ generated triazoline intermediate. Control experiments prove that the electron withdrawing ester group in the enamine component is crucial in inducing the chemo-selective formation of amidines. The method is featured with high efficiency and sustainability by employing pure water as medium without requiring any catalyst or additive.

N -Sulfonyl acetylketenimine as a highly reactive intermediate for the synthesis of N -sulfonyl amidines

A highly reactive intermediate N-sulfonyl acetylketenimine was generated from a 3-butyn-2-one participating CuAAC/ring-opening method. Its high reactivity due to bearing two EWGs allowed us to offer the first example of a reaction between ketenimine and amide to synthesize N-sulfonyl amidines efficiently.