100902-60-1

Upstream product

• 100902-58-7 (+/-)-cis-9-chloro-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 
• 4584-46-7 (2-chloroethyl)dimethylamine hydrochloride 
• 103921-01-3 (+)-cis-2-(4-methoxyphenyl)-3-hydroxy-5-[2-(dimethylamino)ethyl]-9-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one perchlorate 
• 103921-07-9 3-(2-Amino-6-chloro-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid 
• 103921-05-7 3-(2-Chloro-6-nitro-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid methyl ester 
• 103921-06-8 methyl threo-3-<(2-amino-6-chlorophenyl)thio>-2-hydroxy-3-(4-methoxyphenyl)propionate 
• 96125-49-4 methyl trans-3-(4-methoxyphenyl)glycidate 
• 14371-77-8 6-chloro-2-nitrothiophenol 
• 100938-15-6 (S)-1-(Naphthalene-2-sulfonyl)-pyrrolidine-2-carboxylic acid (2R,3R)-9-chloro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester 
• 100902-61-2 3-(2-Amino-6-chloro-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid 

Downstream Products

• 103921-10-4 (+)-cis-2-(4-methoxyphenyl)-3-acetoxy-5-[2-(dimethylamino)ethyl]-9-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one 
• 103921-00-2 (+)-cis-2-(4-methoxyphenyl)-3-hydroxy-5-[2-(dimethylamino)ethyl]-9-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one 

Relevant academic research and scientific papers

Synthesis of Halogen-Substituted 1,5-Benzothiazepine Derivatives and Their Vasodilating and Hypotensive Activities

In an attempt to improve the effectiveness and duration of the action of diltiazem (1), a 1,5-benzothiazepine calcium channel blocker, its derivatives (2) with halogen substituents on the fused benzene ring were synthesized.These compounds were evaluated for their effects on vertebral and coronary blood flows and antihypertensive activity.The structure-activity relationships are discussed.The 8-chloro derivative ((+)-2b), the most potent compound in this series, was selected for clinical evaluation as a cerebral vasodilating and antihypertensive agent.

Novel 9-chloro-1,5-benzothiazepine derivatives and their pharmaceutical use

Novel 1,5-benzothiazepine derivative of the formula: STR1 wherein R1 is hydrogen or lower alkanoyl and each of R2 and R3 is lower alkyl, and a pharmaceutically acceptable acid addition salt thereof are disclosed. Said deri

1,5-benzothiazepine derivatives and processes for preparing the same

Novel 1,5-benzothiazepine derivatives of the formula: STR1 wherein R 1 is hydrogen or lower alkyl, R 2 is hydrogen, lower alkanoyl or benzyl, R 3 is hydrogen or lower alkyl and either one of R 4 and R 5 is hydrogen and the other is chlorine, or a pharmace