1009026-33-8Relevant articles and documents
Pd-P(t-Bu)3-catalyzed consecutive cross-coupling of p-phenylenedizinc compound with two different electrophiles leading to unsymmetrically 1,4-disubstituted benzenes
Kawamoto, Takahiro,Ejiri, Shogo,Kobayashi, Kana,Odo, Shunsuke,Nishihara, Yasushi,Takagi, Kentaro
, p. 1601 - 1604 (2008)
(Chemical Equation Presented) Pd-P(t-Bu)3 was found to be a chemoselective catalyst for the reaction of p-phenylenedizinc compound with equimolar amounts of carbon electrophiles to afford the single cross-coupling products in good yields, effectively suppressing the formation of double cross-coupling products. The subsequent additions of other electrophiles to the resulting solutions caused the second cross-coupling of the incipient products to take place, achieving a novel and efficient one-pot synthesis of unsymmetrically 1,4-disubstituted benzenes. The origin of the observed high chemoselectivity was speculated.
