1009031-39-3Relevant academic research and scientific papers
Carboxylic acid based quinolines as liver X receptor modulators that have LXRβ receptor binding selectivity
Hu, Baihua,Quinet, Elaine,Unwalla, Rayomand,Collini, Mike,Jetter, James,Dooley, Rebecca,Andraka, Diane,Nogle, Lisa,Savio, Dawn,Halpern, Anita,Goos-Nilsson, Annika,Wilhelmsson, Anna,Nambi, Ponnal,Wrobel, Jay
, p. 54 - 59 (2008/09/17)
A series of potent and binding selective LXRβ agonists was developed using the previously reported non-selective LXR ligand WAY-254011 as a structural template. With the aid of molecular modeling, it was found that 2,3-diMe-Ph, 2,5-diMe-Ph, and naphthalene substituted quinoline acetic acids (such as quinoline 33, 37, and 38) showed selectivity for LXRβ over LXRα in binding assays.
