1009121-53-2Relevant academic research and scientific papers
1-Hydroxy-2-pyridinone-based MMP inhibitors: Synthesis and biological evaluation for the treatment of ischemic stroke
Zhang, Yue-Mei,Fan, Xiaodong,Chakaravarty, Devraj,Xiang, Bangping,Scannevin, Robert H.,Huang, Zhihong,Ma, Jianya,Burke, Sharon L.,Karnachi, Prabha,Rhodes, Kenneth J.,Jackson, Paul F.
, p. 409 - 413 (2008/09/16)
Matrix metalloproteinase-9 (MMP-9) has been implicated in the breakdown of the blood-brain barrier during cerebral ischemia. As a result, inhibition of MMP-9 may have utility as a therapeutic intervention in stroke. Towards this end, we have synthesized a series of 1-hydroxy-2-pyridinones that have excellent in vitro potency in inhibiting MMP-9 in addition to MMP-2. Representative compounds also demonstrate good efficacy in the mouse transient mid-cerebral artery occlusion (tMCAO) model of cerebral ischemia.
HETEROCYCLIC DERIVED METALLOPROTEASE INHIBITORS
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Page/Page column 63, (2008/06/13)
This invention provides novel heterocyclic derived matrix metalloprotease inhibitors of the formula: and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing matrix metalloproteases. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.
