100924-68-3

Basic information

• Product Name: 2-((2-dimethylaminobenzyl)sulfinyl)benzimidazole
• Synonyms: 2-((2-dimethylaminobenzyl)sulfinyl)benzimidazole;N,N-Dimethyl-2-[[(1H-benzimidazol-2-yl)sulfinyl]methyl]benzenamine;NC-1300
• CAS NO: 100924-68-3
• Molecular Formula: C₁₆H₁₇N₃OS
• Molecular Weight: 299.39
• Mol File: 100924-68-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 554.4°Cat760mmHg
• Flash Point: 289.1°C
• Appearance: /
• Density: 1.34g/cm³
• Vapor Pressure: 2.47E-12mmHg at 25°C
• Refractive Index: 1.716
• CAS DataBase Reference: 2-((2-dimethylaminobenzyl)sulfinyl)benzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((2-dimethylaminobenzyl)sulfinyl)benzimidazole(100924-68-3)
• EPA Substance Registry System: 2-((2-dimethylaminobenzyl)sulfinyl)benzimidazole(100924-68-3)

Safety Data

• Hazardous Substances Data: 100924-68-3(Hazardous Substances Data)

Usage

Chemical structure

Benzimidazole derivative containing a sulfoxide functional group

Function

Proton pump inhibitor

Mechanism of action

Inhibits the enzyme responsible for the final step in the production of gastric acid

Uses

Treatment of conditions such as gastroesophageal reflux disease (GERD), ulcers, and Zollinger-Ellison syndrome

InChI:InChI=1/C16H17N3OS/c1-19(2)15-10-6-3-7-12(15)11-21(20)16-17-13-8-4-5-9-14(13)18-16/h3-10H,11H2,1-2H3,(H,17,18)

Upstream product

• 144-55-8 sodium hydrogencarbonate 
• 104340-38-7 2-[(1H-Benzimidazol-2-yl)thiomethyl]-N,N-dimethylbenzenamine 
• 106771-59-9 2-(chloromethyl)-N,N-dimethylaniline 
• 134469-07-1 Benzimidazol-2-thiol 

Relevant articles and documents

2-?(1H-benzimidazol-2-ylsulfinyl)methyl!benzenamines

This invention relates to 2-?(1H-benzimidazol-2-ylsulfinyl)methyl!benzenamines that are useful in the treatment and prevention of ulcers.

Stabilized benzimidazole derivative and composition

A stabilized physiologically active benzimidazole derivative having the formula (I): STR1 wherein R1 is hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a fluoroalkyl group having 1 to 6 carbon atoms, a cycloalkyl group, phenyl group or an aralkyl group, R2 is hydrogen atom or a lower alkyl group, or R1 and R2 together with the adjacent nitrogen atom form a ring, and each of R3a, R3b, R4a, R4b and R4c independently is hydrogen atom, a halogen atom, a fluoroalkyl group having 1 to 6 carbon atoms, a lower alkyl group, a lower alkoxy group, a lower alkoxycarbonyl group or an amino group. The stabilized benzimidazole derivative is in amorphous form or present in contact with a basic material.

Method of protecting gastrointestinal tract

A method of protecting gastrointestinal tract in a mammal from the untoward, non-gastric-acid-induced effects of exposure to gastrointestinally injuruous agents, which comprises administering orally to said mammal a non-antisecretory amount of a benzimidazole derivative having the formula (I): STR1 wherein R1 is the hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group, phenyl group or aralkyl group, R2 is the hydrogen atom or a lower alkyl group, or R1 and R2 together with the adjacent nitrogen atom forms a ring, and each of R3 and R4 independently is the hydrogen atom, a halogen atom, the trifluoromethyl group, a lower alkyl group, a lower alkoxy group, a lower alkoxycarbonyl group or an amino group.