1009309-82-3Relevant academic research and scientific papers
Scaled-up transition-metal-catalyzed cross-coupling reactions of thioether-substituted N-heterocycles with organozinc reagents
Metzger, Albrecht,Melzig, Laurin,Knochel, Paul
experimental part, p. 2853 - 2858 (2010/10/03)
A variety of functionalized methylthio-substituted N-heterocycles (pyridines, pyrimidines, pyrazines, pyridazines, triazines, quinazolines, benzothiazoles) undergo smooth palladium- or nickel-catalyzed cross-couplings with highly functionalized organozinc reagents at ambient temperature. No expensive copper(I) salts are required and the coupling reactions proceed readily in the range of up to 20 mmol scale. Georg Thieme Verlag Stuttgart.
An unusual reaction of benzalaminoacetals in trifluoroacetic acid: Facile synthesis of 2-benzylpyrazines
Augustine, John Kallikat,Naik, Yanjerappa Arthoba,Mandal, Ashis Baran,Kundapur, Umesha
, p. 1176 - 1179 (2008/09/18)
(Chemical Equation Presented) Benzalaminoacetals (1), upon refluxing with trifluoroacetic acid, lead to 2-benzylpyrazines, rather than the expected isoquinolines. This unusual reaction represents another useful way to prepare a variety of 2-benzylpyrazines from the corresponding benzaldehydes.
