1009367-72-9Relevant academic research and scientific papers
Catalytic Asymmetric Chlorocyclization of 2-Vinylphenylcarbamates for Synthesis of 1,4-Dihydro-2H-3,1-benzoxazin-2-one Derivatives
Yu, Yan-Min,Huang, Ya-Nan,Deng, Jun
supporting information, p. 1224 - 1227 (2017/03/14)
A facile synthetic approach to a series of chiral 4-chloromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one derivatives has been described. This transformation is achieved through the catalytic asymmetric chlorocyclization of 2-vinylphenylcarbamates using a newly developed organocatalyst. Furthermore, the resulting products can be easily converted into diverse bioactive agents.
Convenient synthesis of 1,4-dihydro-2H-3,1-benzoxazin-2-ones by iodocyclization of t-butyl 2-vinylphenylcarbamates
Kobayashi, Kazuhiro,Fukamachi, Shuhei,Nakamura, Daizo,Morikawa, Osamu,Konishi, Hisatoshi
, p. 95 - 105 (2008/09/20)
It has been found that t-butyl 2-vinylphenylcarbamate derivatives underwent iodocyclization on treatment with iodine in the presence of sodium hydrogencarbonate to afford 4-iodomethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one derivatives in generally good yields. The reduction of these 4-iodomethyl derivatives with tributyltin hydride gave the corresponding 4-methyl derivatives in good yields.
