100937-47-1

Basic information

• Product Name: Methyl 2-(2,3-dihydrospiro[indene-1,4'-piperidin]-3-yl)acetate
• Synonyms: Methyl 2-(2,3-dihydrospiro[indene-1,4'-piperidin]-3-yl)acetate
• CAS NO: 100937-47-1
• Molecular Formula: C16H21NO2
• Molecular Weight: 152.193
• EINECS: -0
• Mol File: 100937-47-1.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Methyl 2-(2,3-dihydrospiro[indene-1,4'-piperidin]-3-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-(2,3-dihydrospiro[indene-1,4'-piperidin]-3-yl)acetate(100937-47-1)
• EPA Substance Registry System: Methyl 2-(2,3-dihydrospiro[indene-1,4'-piperidin]-3-yl)acetate(100937-47-1)

Safety Data

• Hazardous Substances Data: 100937-47-1(Hazardous Substances Data)

Upstream product

• 121701-13-1 (1S,2S,3R,4R)-2-((R)-(1S,2R,4R)-2-Hydroxy-7,7-dimethyl-bicyclo[2.2.1]hept-1-ylmethanesulfinyl)-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid dimethyl ester 
• 129887-42-9 (1S,2S,6R,7R)-2-((R)-(1S,2R,4R)-2-Hydroxy-7,7-dimethyl-bicyclo[2.2.1]hept-1-ylmethanesulfinyl)-4-oxa-tricyclo[5.2.1.0^2,6]dec-8-en-3-one 
• 96243-74-2 (1S,2R,3S,4R)-3-(methoxycarbonyl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid 
• 116877-08-8 (1R,2R,5S,6S,7S)-5-hydroxymethyl-4-oxatricyclo(5.2.1.0^2,6)decan-3-one 
• 117063-99-7 (2R,5S,6S)-5-hydroxymethyl-4-oxa-endo-tricyclo<5.2.1.0^2.6>dec-8-en-3-one 
• 542-92-7 cyclopenta-1,3-diene 
• 193467-07-1 (1S,2R,3S,4R)-3-[1,3]Dithian-2-yl-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid methyl ester 
• 193467-06-0 (1R,2S,3R,4S)-3-[1,3]Dithian-2-yl-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid methyl ester 
• 193467-08-2 ((1R,2S,3R,4S)-3-[1,3]Dithian-2-yl-bicyclo[2.2.1]hept-5-en-2-yl)-methanol 
• 5062-97-5 cis-exo-2,3-bis(hydroxymethyl)bicyclo<2.2.1>heptane 
• 29910-09-6 N-phenyltricyclo[2.2.1]heptane-2β,6β-dicarboximide 
• 17812-27-0 cis-5-norbornene-endo-2,3-dicarboxylic anhydride 
• 115269-21-1 (2R,6S)-4-oxatricyclo[5.2.1.0^2,6]dec-8-en-3-one 

Downstream Products

• 128208-12-8 (1R,2R,3S,4S)-3-Benzenesulfonylmethyl-bicyclo[2.2.1]heptane-2-carboxylic acid 
• 128208-11-7 (1R,2R,3S,4S)-3-Phenylsulfanylmethyl-bicyclo[2.2.1]heptane-2-carboxylic acid 

Relevant articles and documents

Asymmetric Catalytic Reduction of meso-Imides

A thiazazincolidine complex, 1, was shown to be an excellent catalyst for enantioselective reduction with bis(2,6-dimethylphenoxy)borane (BDMPB) of meso N-phenylimides in high ee to the corresponding hydroxy lactams, which were eventually converted to the corresponding lactones of high optical purity.

Catalytic asymmetric oxidative lactonizations of meso-diols using a chiral iridium complex

A chiral amino alcohol/Ir complex catalyzes the asymmetric oxidative lactonizations of meso-diols to give the corresponding lactones in up to 81% ee.

Enantioselective reduction of meso-cyclic-1,2-dicarboxylic anhydrides and 1,2-dicarboximides: Asymmetric synthesis of bicyclic lactones and hydroxylactams

Chiral bicyclic lactones (3,8,9) and bicyclic hydroxylactams (10-13) were synthesized by highly enantioselective reduction of meso-cyclic-1,2- dicarboxylic anhydrides (1, 4) and meso-cyclic-1,2-dicarboximides (2) with lithium aluminum hydride (LiAlH4)-alcohol(ROH)-(R)- or (S)-1,1'-bi-2- naphthol complex [(R)- or (S)-BINAL-H(ROH)]. Treatment of the hydroxylactams (10-13) with triethylsilane (Et3SiH) and trifluoroacetic acid (CF3CO2H) gave chiral bicyclic lactams (14, 15) in quantitative yields. Removal of the N-4-methoxyphenyl group of the lactams (14, 15) with cerium(IV) ammonium nitrate (CAN) proceeded smoothly to give the corresponding N-unsubstituted lactams (16, 17) in high optical purity.