100948-83-2

Basic information

• Product Name: 1,3-Dichloro-5-Methoxy-2-nitrobenzene
• Synonyms: Benzene, 1,3-dichloro-5-methoxy-2-nitro-
• CAS NO: 100948-83-2
• Molecular Formula: C₇H₅Cl₂NO₃
• Molecular Weight: 222.0255
• Mol File: 100948-83-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1,3-Dichloro-5-Methoxy-2-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dichloro-5-Methoxy-2-nitrobenzene(100948-83-2)
• EPA Substance Registry System: 1,3-Dichloro-5-Methoxy-2-nitrobenzene(100948-83-2)

Safety Data

• Hazardous Substances Data: 100948-83-2(Hazardous Substances Data)

Usage

General Description

1,3-Dichloro-5-Methoxy-2-nitrobenzene is a chemical compound with the molecular formula C7H5Cl2NO3. It is a yellow solid that is mainly used in organic synthesis and chemical research. This chemical is known for its nitro and methoxy substituents, which make it a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its properties and reactivity also make it a useful compound in the development of new materials and in the field of chemical engineering. However, it is important to handle this compound with care due to its potential toxicity and environmental impact.

Upstream product

• 50590-08-4 3,5-dichloro-4-nitrophenol 
• 77-78-1 dimethyl sulfate 
• 74672-02-9 3,5-dichloro-2-nitrophenol 
• 33719-74-3 3,5-dichloroanisole 
• 591-35-5 3,5-dichlorophenol 

Downstream Products

• 6480-66-6 2,6-dichloro-4-methoxyaniline 
• 93839-14-6 2,4-dichloro-6-methoxyaniline 
• 6478-34-8 3,5-dichloro-4-nitroso-anisole 
• 244037-19-2 2,3,5-trichloro-4-iodoanisole 
• 98273-17-7 1,3-dichloro-2-iodo-5-methoxybenzene 
• 90-25-5 chloro-dimethoxynitrobenzene 

Relevant articles and documents

Synthesis of sterically hindered polychlorinated biphenyl derivatives

A series of sterically hindered (methoxylated) polychlorinated biphenyl derivatives were synthesized using the Suzuki and the Ullmann coupling reactions. The Suzuki coupling with Pd(dba)2-dicyclohexylphosphino-2,6- dimethoxybiphenyl (DPDB) gave better yields (65-98%) compared to the classic Ullmann coupling reaction (20-38%). Despite the reactive catalyst system, no significant coupling with aromatic chlorine substituents was observed. Crystal structure analysis of four PCB derivatives revealed solid state dihedral angles ranging from 69.7 to 81.0, which indicates that these highly ortho-substituted PCB derivatives have some conformational flexibility. Georg Thieme Verlag Stuttgart.

Synthesis of deuterium labelled 4'-hydroxydiclofenac

Diclofenac is a potentially useful substrate for the study of drug-drug interactions caused by modulation of the activity of specific isoforms of cytochrome P450. The synthesis of a deuterium labelled version of its principal human metabolite, 4'-hydroxydiclofenac, for use as an internal standard in LC-MS-MS studies, is described.