100963-83-5Relevant academic research and scientific papers
Photocatalytic carbanion generation from C-H bonds-reductant free Barbier/Grignard-type reactions
Berger, Anna Lucia,Donabauer, Karsten,K?nig, Burkhard
, p. 10991 - 10996 (2019/12/28)
We report a redox-neutral method for the generation of carbanions from benzylic C-H bonds in a photocatalytic Grignard-type reaction. The combination of photo- and hydrogen atom transfer (HAT) catalysis enables the abstraction of a benzylic hydrogen atom, generating a radical intermediate. This radical is reduced in situ by the organic photocatalyst to a carbanion, which is able to react with electrophiles such as aldehydes or ketones, yielding homobenzylic secondary and tertiary alcohols.
