1009643-89-3Relevant academic research and scientific papers
Synthesis of new pyrrolidine-based organocatalysts and study of their use in the asymmetric Michael addition of aldehydes to nitroolefins
Castán, Alejandro,Badorrey, Ramón,Gálvez,Díaz-De-Villegas
supporting information, p. 612 - 619 (2017/06/20)
New pyrrolidine-based organocatalysts with a bulky substituent at C2 were synthesized from chiral imines derived from (R)-glyceraldehyde acetonide by diastereoselective allylation followed by a sequential hydrozirconation/iodination reaction. The new compounds were found to be effective organocatalysts for the Michael addition of aldehydes to nitroolefins and enantioselectivities up to 85% ee were achieved.
Superparamagnetic nanoparticle-Supported (S)-diphenyl- prolinol trimethylsilyl ether as a recyclable catalyst for asymmetric Michael addition in water
Wang, Bang Gen,Ma, Bao Chun,Wang, Qiong,Wang, Wei
supporting information; experimental part, p. 2923 - 2928 (2011/02/22)
A new superparamagnetic nanoparticle-supported (S)-diphenylprolinol trimethylsilyl ether (Jorgensen-Hayashi catalyst) was synthesized and applied for the asymmetric Michael addition of aldehydes to nitroalkenes in water, which gives products in moderate t
Highly efficient catalytic system for enantioselective Michael addition of aldehydes to nitroalkenes in water
Zhu, Shaolin,Yu, Shouyun,Ma, Dawei
, p. 545 - 548 (2008/09/21)
(Chemical Equation Presented) Organocatalysis: A highly effective catalytic procedure for the Michael addition of aldehydes to nitroalkenes is achieved by combining the excellent asymmetric induction ability of o-TMS-protected diphenylprolinol compounds, the quick formation of enamines in the presence of benzoic acid, and the highly concentrated organic phase in water (see scheme; TMS=trimethylsilyl).
