100965-24-0Relevant articles and documents
Role of water and phase transfer catalysts in the kinetics of condensation of diaryl ketones with acetonitrile initiated by solid potassium hydroxide
Bentley, T. William,Jones, Ray V. H.,Larder, Annette H.,Lock, Stephen J.
, p. 89 - 94 (1998)
The kinetics of reactions of benzophenone and substituted derivatives with acetonitrile in the presence of excess solid potassium hydroxide (KOH) to give 2,2-diarylacrylonitriles are reported. Reaction rates are strongly temperature dependent, and water,
Synthesis and biological activity of allosteric modulators of GABA B receptors, Part 1. N-(Phenylpropyl)-1-arylethylamines
Kerr, David I. B.,Ong, Jennifer,Perkins, Michael V.,Prager, Rolf H.,Puspawati, Ni Made
, p. 445 - 456 (2006)
A series of 15 analogues of fendiline, and 34 derivatives of N-(3-phenylpropyl)-1-arylethylamine have been prepared for evaluation as positive allosteric modulators of GABAB receptors. The most active (EC50, 10 nM) was N-(3,3-diphenylpropyl)-1-(3-chloro-4-methoxyphenyl) ethylamine 6g. CSIRO 2006.
Silver-Catalyzed Long-Distance Aryl Migration from Carbon Center to Nitrogen Center
Zhou, Taigang,Luo, Fei-Xian,Yang, Ming-Yu,Shi, Zhang-Jie
supporting information, p. 14586 - 14589 (2015/12/08)
Selective cleavage of an inert C-C bond followed by C-O/N bond formation through a long-distance aryl migration from a carbon to a nitrogen center via Ag catalysis is reported. The migration products were easily converted into γ-hydroxy amines and tetrahy
Synthesis of acrylonitriles through an FeCl3-catalyzed domino propargylic substitution/aza-Meyer-Schuster rearrangement sequence
Hao, Lu,Wu, Feng,Ding, Zong-Cang,Xu, Su-Xia,Ma, Yan-Li,Chen, Li,Zhan, Zhuang-Ping
supporting information; experimental part, p. 6453 - 6456 (2012/06/15)
Nontoxic cyanide source: An unprecedented route to acrylonitriles by employing propargylic alcohols and para-tolylsulfonohydrazide as a combined cyano source has been developed (see scheme). This efficient and practical cyanation reaction proceeds through an FeCl3-catalyzed domino propargylic substitution/aza-Meyer-Schuster rearrangement sequence, the rearrangement process of which is reported for the first time. Copyright
Mono- and β,β-double-heck reactions of α,β-unsaturated carbonyl compounds in aqueous media
Botella, Luis,Najera, Carmen
, p. 4360 - 4369 (2007/10/03)
Optimized reaction conditions for the mono- and β,β-diarylation of electron-deficient alkenes in aqueous media catalyzed either by a p-hydroxyacetophenone oxime-derived palladacycle or by palladium(II) acetate under phosphine-free conditions and in the presence of (dicyclohexyl)- methylamine as base are described. Regioselective monoarylation of unsubstituted and substituted α,β-unsaturated carbonyl compounds takes place with aryl iodides at 120 °C in water. Aqueous N,N-dimethylacetamide (DMA), tetra-n-butylammonium bromide (TBAB) as additive, and the palladacycle as catalyst are the most efficient conditions for the coupling with aryl bromides, good stereoselectivities being also obtained in the arylation of crotonates and itaconates, whereas cinnamic derivatives afford lower steroselectivity, with the exception of cinnamic acid and nitrile. β,β-Diarylation of unsubstituted α,β-unsaturated carbonyl compounds can be controlled by using higher loading of the palladacycle and can be performed in refluxing water for aryl iodides, whereas DMA must be used for aryl bromides. Microwave irradiation can be used in the monoarylation of tertbutyl acrylate with aryl iodides in water or the coupling between ethyl cinnamate and aryl bromides in aqueous DMA.
