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10097-02-6 Usage


2,2-Bis(hydroxymethyl)butyric acid, also known as THB, is an organic compound with the molecular formula C6H12O4. It is a colorless, odorless liquid at room temperature and is soluble in water. THB is characterized by its two hydroxymethyl groups attached to a butyric acid backbone, which provides it with unique properties and makes it suitable for various applications.


Used in Water Soluble Polyurethane (PU) Systems:
2,2-Bis(hydroxymethyl)butyric acid is used as a crosslinking agent and hydrophilic agent in the water-soluble PU system. Its ability to form crosslinks enhances the mechanical properties and durability of the PU materials, while its hydrophilic nature improves their compatibility with water-based systems.
Used in Polyester Resin and Epoxy Ester:
THB is utilized as a crosslinking agent in polyester resins and epoxy esters, contributing to the formation of a robust and stable network structure. This results in improved mechanical strength, chemical resistance, and thermal stability of the final products.
Used in Coating Applications:
Due to its good solubility in water, 2,2-Bis(hydroxymethyl)butyric acid is widely used in the coating industry, particularly for water-soluble PU system coatings, adhesives, and leather coating agents. Its incorporation into these formulations enhances the water resistance, adhesion, and overall performance of the coatings.
Used as a Monomer for Water Soluble Polyurethanes and Polyesters:
THB serves as a monomer in the synthesis of water-soluble polyurethanes and polyesters. Its unique structure allows for the creation of polymers with tailored properties, such as hydrophilicity, mechanical strength, and flexibility, making them suitable for a wide range of applications.
Used as an Environmentally Friendly Substitute:
2,2-Bis(hydroxymethyl)butyric acid is considered a new, environmentally friendly alternative to 2,2-Bis(hydroxymethyl)propionic acid. Its use in various applications helps reduce the environmental impact associated with the production and disposal of traditional chemicals.

Flammability and Explosibility


Check Digit Verification of cas no

The CAS Registry Mumber 10097-02-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,0,9 and 7 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 10097-02:
66 % 10 = 6
So 10097-02-6 is a valid CAS Registry Number.

10097-02-6 Well-known Company Product Price

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  • Aldrich

  • (470627)  2,2-Bis(hydroxymethyl)butyricacid  98%

  • 10097-02-6

  • 470627-100G

  • 644.67CNY

  • Detail
  • Vetec

  • (V900528)  2,2-Bis(hydroxymethyl)butyricacid  Vetec reagent grade, 98%

  • 10097-02-6

  • V900528-100G

  • 321.75CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017


1.1 GHS Product identifier

Product name 2,2-Bis(hydroxymethyl)butyric acid

1.2 Other means of identification

Product number -
Other names 2,2'-bis(hydroxymethyl)butyric acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10097-02-6 SDS

10097-02-6Synthetic route



2,2-bis(hydroxymethyl)butanoic acid

2,2-bis(hydroxymethyl)butanoic acid

With toluene-4-sulfonic acid In ethanol; water at 80℃; for 24h;93.1%


2,2-bis(hydroxymethyl)butanoic acid

2,2-bis(hydroxymethyl)butanoic acid

With dihydrogen peroxide at 50 - 70℃; for 2h; Temperature;81.6%
With dihydrogen peroxide
With dihydrogen peroxide


sodium butyrate

sodium butyrate

2,2-bis(hydroxymethyl)butanoic acid

2,2-bis(hydroxymethyl)butanoic acid

at 150℃; for 70h;


2,2-bis(hydroxymethyl)butanoic acid

2,2-bis(hydroxymethyl)butanoic acid

With potassium permanganate

10097-02-6Relevant articles and documents

Ab initio structure determination of monoclinic 2,2-dihydroxymethylbutanoic acid from synchrotron radiation powder diffraction data: Combined use of direct methods and the Monte Carlo method

Tanahashi, Yusaku,Nakamura, Hisayoshi,Yamazaki, Satoru,Kojima, Yuko,Saito, Hideshi,Ida, Takashi,Toraya, Hideo

, p. 184 - 189 (2001)

The crystal structure of 2,2-dihydroxymethylbutanoic acid (C6H12O4) in monoclinic form has been determined ab initio from synchrotron radiation powder diffraction data. Two O and five C atoms were first derived by direct methods. Two missing O atoms and one C atom were found by the Monte Carlo method without applying constraint to their relative positions. Positional and isotropic displacement parameters of these non-H atoms were refined by the Rietveld method. Molecules are linked by hydrogen bonds and they make sheet-like networks running parallel to the (010) plane. The Monte Carlo method is demonstrated to be a powerful tool for finding missing atoms in partially solved structure.

Preparation method of 2,2-dimethylolbutyric acid


Paragraph 0029-0041; 0043-0045, (2019/10/01)

The invention discloses a preparation method of 2,2-dimethylolbutyric acid; beta, beta-dihydroxymethyl butyraldehyde is produced by reaction of butyraldehyde and polyformaldehyde as raw materials under the action of an organic base catalyst, the beta, beta-dihydroxymethyl butyraldehyde is oxidized under the action of hydrogen peroxide to obtain beta, beta-dihydroxymethyl butyric acid, the beta, beta-dihydroxymethyl butyric acid is neutralized by an inorganic base to obtain beta, beta-dihydroxymethyl butyrate, and the beta, beta-dihydroxymethyl butyrate is distilled and filtered to obtain highpurity beta, beta-dihydroxymethyl butyrate, and finally, the 2,2-dimethylolbutyric acid is obtained by acidification of the high purity beta, beta-dihydroxymethyl butyrate under the action of an acid.The preparation method is characterized in that the 2,2-dimethylolbutyric acid is prepared by a new synthesis method, a recrystallization step in the traditional process is omitted, the reaction efficiency is high, the product is easy to separate, the yield of the product can be greatly improved, the waste is less, and the design idea of green chemistry is met.

Cosmetic or dermatological topical compositions comprising dendritic polyesters


, (2008/06/13)

The present invention relates to cosmetic or dermatological compositions capable of being applied to the skin, the keratinous fibers, the nails, the semimucous membranes and/or the mucous membranes, and which includes a dendritic polyester polymer having terminal hydroxyl functional groups or the combination of such a polymer with a film-forming polymer. It also relates to methods of cosmetic or dermatological treatment using these compositions as well as the use of the compositions for the preparation of dermatological or cosmetic compositions.

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